Genomic and Proteomic Study of Cancer Disparities in Et*

Et* 癌症差异的基因组和蛋白质组研究

• 批准号: 6488576
• 负责人: LISA C. FLOWERS
• 金额: $ 17.06万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6488576
• 关键词: clinical research; cooperative study; functional /structural genomics; genetic polymorphism; health science research potential; neoplasm /cancer epidemiology; proteomics; racial /ethnic difference

DESCRIPTION: (Applicant's Description) This proposal seeks to devise a working plan for establishing a long-term collaboration between Clark Atlanta University and Emory School of Medicine, Winship Cancer Institute. Clark Atlanta University, a historically comprehensive Blaek University and Winship Cancer Institute are only a few miles apart but have not had extensive collaborations in the past. The objectives of this proposal are to plan, and establish new collaborations and research efforts, and to expand existing collaborations between Clark Atlanta University and the Winship Cancer Institute. The emphasis of this collaboration is the study of cancer disparities between ethnic populations using genomic and proteomic approaches. The honest evaluation and mutual respect of each institutions' strengths and weaknesses are recognized, allowing for organized development of collaborative arrangements that make best use of each institutions resources. This proposal intends to further develop pilot research projects, to conduct at each institution regular seminars, and quarterly advisory meetings over the term of the grant. Using microarray technology, phage display and mutational analysis collaborators at Clark Atlanta University and Emory School of Medicine, Winship Cancer Institute will directly address in differences between the gene and antigen expression profiles and mutational events that could illuminate the differences in cancer occurrence between the two populations. The final goal of this project is to generate more funding opportunities (i.e. R-series grants) for Clark Atlanta University and to provide an increasing involvement of Winship Cancer Institute in the study of cancer disparities between ethnic populations.

描述：（申请人的描述）本提案寻求设计一种 克拉克·亚特兰大公司建立长期合作关系的工作计划 大学和埃默里医学院，温希普癌症研究所。克拉克 亚特兰大大学，一所历史悠久的综合性大学 癌症研究所只有几英里远，但没有广泛的 过去的合作。本提案的目标是规划， 建立新的合作和研究工作，并扩大现有的 克拉克亚特兰大大学和温希普癌症研究所之间的合作 院这次合作的重点是癌症的研究 使用基因组学和蛋白质组学方法研究种族人群之间的差异。 诚实评估和相互尊重每个机构的优势， 认识到存在的弱点，允许有组织地发展合作 最大限度地利用每个机构的资源。这项建议 打算进一步发展试点研究项目， 定期举办研讨会，每季度召开咨询会议， 补助金利用微阵列技术、噬菌体展示和突变分析 克拉克亚特兰大大学和埃默里医学院的合作者， Winship癌症研究所将直接解决基因之间的差异， 抗原表达谱和突变事件 这两个群体之间癌症发生率的差异。最终 本项目的目标是创造更多的融资机会（即R系列 克拉克亚特兰大大学，并提供越来越多的参与 Winship癌症研究所在研究种族之间的癌症差异 人口。