Genomic and Proteomic Study of Cancer Disparities in Et*

描述：(申请人的描述)这项建议旨在设计一种 建立克拉克·亚特兰大之间长期合作的工作计划 大学和埃默里医学院，Winship癌症研究所。克拉克 亚特兰大大学，历史上综合性的布莱克大学和温希普大学 癌症研究所相距只有几英里远，但并没有广泛的 过去的合作。这项提案的目标是计划，以及 建立新的合作和研究努力，并扩大现有的 克拉克·亚特兰大大学与温希普癌症研究所的合作 研究所。这次合作的重点是癌症研究。 使用基因组和蛋白质组方法的种族群体之间的差异。 诚实评估和相互尊重每个机构的优势和 认识到弱点，允许有组织地开发协作 充分利用各机构资源的安排。这项建议 打算进一步开发试点研究项目，在每个项目中进行 机构定期研讨会和季度咨询会议，任期为 奖助金。利用基因芯片技术，噬菌体展示和突变分析 克拉克·亚特兰大大学和埃默里医学院的合作者， Winship癌症研究所将直接解决基因之间的差异 以及抗原表达谱和突变事件可以说明 两种人群在癌症发生方面的差异。决赛 该项目的目标是创造更多的融资机会(即R系列 给克拉克·亚特兰大大学)，并提供更多的参与 温希普癌症研究所在研究不同种族之间的癌症差异 人口。

DESCRIPTION: (Applicant's Description) This proposal seeks to devise a working plan for establishing a long-term collaboration between Clark Atlanta University and Emory School of Medicine, Winship Cancer Institute. Clark Atlanta University, a historically comprehensive Blaek University and Winship Cancer Institute are only a few miles apart but have not had extensive collaborations in the past. The objectives of this proposal are to plan, and establish new collaborations and research efforts, and to expand existing collaborations between Clark Atlanta University and the Winship Cancer Institute. The emphasis of this collaboration is the study of cancer disparities between ethnic populations using genomic and proteomic approaches. The honest evaluation and mutual respect of each institutions' strengths and weaknesses are recognized, allowing for organized development of collaborative arrangements that make best use of each institutions resources. This proposal intends to further develop pilot research projects, to conduct at each institution regular seminars, and quarterly advisory meetings over the term of the grant. Using microarray technology, phage display and mutational analysis collaborators at Clark Atlanta University and Emory School of Medicine, Winship Cancer Institute will directly address in differences between the gene and antigen expression profiles and mutational events that could illuminate the differences in cancer occurrence between the two populations. The final goal of this project is to generate more funding opportunities (i.e. R-series grants) for Clark Atlanta University and to provide an increasing involvement of Winship Cancer Institute in the study of cancer disparities between ethnic populations.