Clinical Trials Network: New Mexico Node

临床试验网络：新墨西哥节点

• 批准号: 6793944
• 负责人: WILLIAM R. MILLER
• 金额: $ 2.61万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6793944
• 关键词: antipsychotic agents; behavior test; behavior therapy; behavioral /social science research tag; borderline personality disorder; clinical research; clinical trials; cocaine; combination therapy; comorbidity; cooperative study; drug /alcohol abstinence; drug abuse; drug abuse chemotherapy; drug abuse therapy; family therapy; human subject; human therapy evaluation; metabolism disorder chemotherapy; methadone; outcomes research; patient oriented research; psychological reinforcement; serotonin inhibitor; substance abuse related behavior; urinalysis

DESCRIPTION (provided by applicant): The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA) submits a revised application to join the NIDA Clinical Trials Network as a Regional Research and Training Center and coordinate a New Mexico Node. CASAA and the collaborating Department of Psychiatry of UNM's School of Medicine have well -established infrastructure for behavioral and pharmacotherapy trials, and long experience with collaborative and multisite trials in the addiction field. Particular strengths that the proposed New Mexico Node team can bring to the CTN include: 1) expertise in "Stage III" research on dissemination and training of evidence-based treatments 2) a well -established track record of clinical trials for both behavioral and pharmacotherapies 3) a high concentration (70%) of minority patients in the affiliated CTP's, and substantial experience in research on cultural influences on and adaptations of drug abuse treatment 4) longstanding experience in the development and evaluation of innovative treatment methods for substance use disorders 5) substantial clinical and research experience with challenging populations including dual disorders, the homeless, and runaway adolescents 6) expertise in studying the influence of mutual help (e.g., 12-step) programs on treatment outcomes, and more generally in research on spirituality and addictions 7) geographic representation of the border Southwest To illustrate CTN-wide research that could be initiated from the New Mexico node, protocol concepts for three clinical trials are described, encompassing a behavioral intervention, a pharmacotherapy, and methods for disseminating an evidence-based treatment into clinical practice.

描述（由申请人提供）：新墨西哥州酒精中毒，药物滥用和成瘾中心（CASAA）的大学提交了一份修订后的申请加入NIDA临床试验网络作为区域研究和培训中心，并协调新墨西哥州节点。CASAA和UNM医学院的精神病学合作部门拥有完善的行为和药物治疗试验基础设施，以及在成瘾领域进行合作和多地点试验的长期经验。拟议的新墨西哥州节点团队可以为CTN带来的特殊优势包括： 1)关于循证治疗传播和培训的“第三阶段”研究的专业知识 2)行为疗法和药物疗法临床试验的良好记录 3)少数民族患者在附属CTP中的高度集中（70%），以及在研究文化对药物滥用治疗的影响和适应方面的丰富经验 4)在开发和评价药物使用障碍创新治疗方法方面的长期经验 5)具有丰富的临床和研究经验，具有挑战性的人群，包括双重障碍，无家可归者和离家出走的青少年 6)研究互助影响的专业知识（例如，12步）的治疗结果，更普遍的是在研究精神和成瘾 7)西南边境的地理代表 为了说明CTN范围内的研究，可以从新墨西哥州节点开始，协议的概念，三个临床试验进行了描述，包括行为干预，药物治疗，并传播到临床实践中的循证治疗的方法。