Clinical Trials Network: New Mexico Node

描述(由申请人提供)：新墨西哥大学酒精中毒、药物滥用和成瘾中心(CASAA)提交了一份修订后的申请，希望加入NIDA临床试验网络，成为一个地区研究和培训中心，并协调新墨西哥节点。CASAA和UNM医学院精神病学合作系在行为和药物治疗试验方面拥有完善的基础设施，并在成瘾领域的合作和多点试验方面拥有长期经验。提议的新墨西哥节点团队可以为CTN带来的特别优势包括： 1)在传播和培训循证治疗的“第三阶段”研究方面的专门知识 2)行为疗法和药物疗法的临床试验的良好记录 3)附属CTP的少数民族患者高度集中(70%)，在药物滥用治疗的文化影响和适应研究方面有丰富的经验 4)在开发和评估药物使用障碍的创新治疗方法方面的长期经验 5)在具有挑战性的人群方面有丰富的临床和研究经验，包括双重障碍、无家可归者和失控青少年 6)研究互助(例如，12步)方案对治疗结果的影响的专门知识，以及更普遍地研究精神和成瘾问题的专门知识 7)西南边界的地理表现 为了说明可以从新墨西哥州节点启动的CTN范围内的研究，描述了三个临床试验的方案概念，包括行为干预、药物治疗和将循证治疗传播到临床实践的方法。

DESCRIPTION (provided by applicant): The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA) submits a revised application to join the NIDA Clinical Trials Network as a Regional Research and Training Center and coordinate a New Mexico Node. CASAA and the collaborating Department of Psychiatry of UNM's School of Medicine have well -established infrastructure for behavioral and pharmacotherapy trials, and long experience with collaborative and multisite trials in the addiction field. Particular strengths that the proposed New Mexico Node team can bring to the CTN include: 1) expertise in "Stage III" research on dissemination and training of evidence-based treatments 2) a well -established track record of clinical trials for both behavioral and pharmacotherapies 3) a high concentration (70%) of minority patients in the affiliated CTP's, and substantial experience in research on cultural influences on and adaptations of drug abuse treatment 4) longstanding experience in the development and evaluation of innovative treatment methods for substance use disorders 5) substantial clinical and research experience with challenging populations including dual disorders, the homeless, and runaway adolescents 6) expertise in studying the influence of mutual help (e.g., 12-step) programs on treatment outcomes, and more generally in research on spirituality and addictions 7) geographic representation of the border Southwest To illustrate CTN-wide research that could be initiated from the New Mexico node, protocol concepts for three clinical trials are described, encompassing a behavioral intervention, a pharmacotherapy, and methods for disseminating an evidence-based treatment into clinical practice.