Epigenetic Changes in the Prostate Cancer Microenvironment

前列腺癌微环境的表观遗传变化

• 批准号: nhmrc : 1106870
• 负责人: Dr Mitchell Lawrence
• 金额: $ 58.23万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-changes-prostate-cancer-microenvironment/662939
• 关键词: Epigenetic; Changes; Prostate; Cancer; Microenvironment

Many men with prostate cancer have slow-growing tumours that are unlikely to spread outside the prostate. These men with low-risk cancer are often monitored to prevent unnecessary aggressive treatments. However, the current methods used to distinguish between slow-growing and aggressive tumours are imprecise and there is a risk of missing aggressive tumours. We aim to identify new biomarkers of prostate cancer by measuring modifications to the DNA in the tumour and surrounding cells

许多前列腺癌患者的肿瘤生长缓慢，不太可能扩散到前列腺外。这些患有低风险癌症的男性经常受到监测，以防止不必要的积极治疗。然而，目前用于区分生长缓慢和侵袭性肿瘤的方法是不精确的，并且存在遗漏侵袭性肿瘤的风险。我们的目标是通过测量肿瘤和周围细胞中DNA的修饰来识别前列腺癌的新生物标志物