Cancer-Associated Fibroblast Stem Cells

前列腺癌细胞的行为受其周围称为间质的环境的调节。间质被认为是一种治疗靶点，但它是一种多样化的细胞混合物，需要进行特定的靶点。并不是所有的间质细胞都是一样的；肿瘤周围的细胞与正常组织中的细胞有不同的特征。因此，该项目的目标是直接从患者组织中分离出与癌症相关的基质细胞，并研究它们在癌症进展中的作用。

The behaviour of prostate cancer cells is regulated by their surrounding environment known as the stroma. The stroma has been proposed as a therapeutic target, but it is a diverse mix of cells that needs to be specifically targeted. Not all stromal cells are equal; cells surrounding tumours have different features from cells in normal tissue. Therefore, the goal of this project is to directly isolate cancer-associated stromal cells from patient tissue and study their role in cancer progression.