POOLING OF PROSPECTIVE STUDIES OF DIET AND CANCER

饮食与癌症前瞻性研究的汇集

• 批准号: 6597573
• 负责人: David John HUNTER
• 金额: $ 27.95万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6597573
• 关键词: carotenoids; clinical research; colorectal neoplasms; diet; human subject; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; ovary neoplasms; pancreas neoplasms

DESCRIPTION: (provided by Applicant) In this application, the aims of the Pooling of Prospective Studies of Diet and Cancer Project (referred to as the Pooling Project) will expand to examine dietary associations with pancreatic and ovarian cancers in large, prospective cohort studies. Expansion of the Pooling Project to these cancers with intermediate incidence rates will take advantage of the statistical power from combining data from multiple studies and the ability to examine a wide range of intakes and subgroup detail. The pooled analyses also allow standardized analytic approaches with standardized categorization of exposures and covariates across studies. Additional analyses of colorectal cancer, a cancer site that is being evaluated as part of the current grant cycle, also will be conducted. The 11 studies comprising the Pooling Project are the Adventist Health Study, Alpha-Tocopherol Beta-Carotene Cancer Prevention Study, Canadian National Breast Screening Study, Cancer Prevention Study II Nutrition Cohort, Iowa Women?s Health Study, Health Professionals Follow-up Study, Netherlands Cohort Study, New York State Cohort, New York University Women?s Health Study, Nurses? Health Study, and Sweden Mammography Cohort. Analyses will include 4,949 colorectal cancer cases and an estimated 1,553 pancreatic and 1,908 ovarian cancer cases. For colorectal cancer, associations with specific carotenoids and grains will be examined. For pancreatic cancer, analyses will evaluate associations with intakes of fruits, vegetables, specific carotenoids, grains, fiber, alcohol, and meat. Analyses of ovarian cancer risk and intakes of lactose, dairy products, fruits, vegetables, antioxidants, fat, eggs, and cholesterol and body mass index will be conducted. The ongoing annual meetings, and frequent communication among investigators, will be used to facilitate the analysis and interpretation of the findings. These analyses will take full advantage of extensive data already collected to provide powerful insight into the relation between diet and the risk of pancreatic, ovarian, colorectal cancer.

描述：（由申请人提供）在本申请中， 饮食与癌症前瞻性研究汇总项目（简称 汇集项目）将扩大到检查饮食与胰腺癌的关系， 和卵巢癌之间的关系。扩大 这些发病率中等的癌症的汇总项目将采取 结合多项研究数据的统计功效优势 以及检查各种摄入量和亚组细节的能力。的 合并分析还允许标准化的分析方法， 研究中暴露和协变量的分类。额外分析 结肠直肠癌，一个癌症部位，正在评估的一部分， 目前的周期，也将进行。11项研究包括 汇集项目是基督复临健康研究，α-生育酚β-胡萝卜素 癌症预防研究，加拿大国家乳腺癌筛查研究，癌症 预防研究II营养队列，爱荷华州妇女？s健康研究，健康 专业人士随访研究，荷兰队列研究，纽约州 队列，纽约大学女生？护士的健康研究健康研究，以及 瑞典乳房X线摄影队列研究。分析将包括4，949例结直肠癌 胰腺癌1,553例，卵巢癌1,908例。为 结直肠癌，与特定的类胡萝卜素和谷物的关联将是 考察对于胰腺癌，分析将评估与 水果、蔬菜、特定类胡萝卜素、谷物、纤维、酒精 还有肉乳糖、乳制品摄入量与卵巢癌风险的分析 产品，水果，蔬菜，抗氧化剂，脂肪，鸡蛋和胆固醇， 将进行体重指数检查。正在举行的年度会议， 研究者之间的沟通，将用于促进分析， 对调查结果的解释。这些分析将充分利用 已经收集了大量的数据，以提供对关系的有力洞察 饮食与胰腺癌、卵巢癌、结肠直肠癌的风险之间的关系。