PEPTIDE BIOCOMPATIBLE POLYMER MACROMOLECULAR COMPLEXES

肽生物相容性聚合物大分子复合物

• 批准号: 6661595
• 负责人: WILLIAM S SEFFENS
• 金额: $ 8.86万
• 依托单位: CLARK ATLANTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-19 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6661595
• 关键词: minority institution research support; proteins

Description: The overall and overarching goal of the proposed studies is the development of fundamental understanding necessary for preparing peptide/biocompatible polymer macromolecular complexes as 21st-century biofunctional materials. In order to accomplish this goal, a detailed understanding of the forces necessary for the formation of stable model peptide/biocompatible polymer complexes will be developed. The forces contributing to the formation of stable complexes are a combination of ion-dipole, hydrophobic and H-bonding interactions, and will be elucidated by using 2-D NOESY NMR spectroscopy, circular dichroism (CD) spectroscopy and light scattering studies in a complementary fashion. Additionally, the current understanding of the formation of stable model peptide/poly(ethylene oxide)(PEO) complexes will be applied to the development of stable PEO/arginine-glycine-aspartic acid (RGD) complex as a bioadhesive extracellular material. The preliminary bioadhesive properties of the PEO/RGD macromolecular complexes will be determined by studying adherence of cells to thin films of the complexes. The adhesive interaction of synthetic extracellular material will find application in controlled and targeted drug delivery to specific organ or cell via a "key and lock" mechanism.

描述：拟议研究的总体和首要目标是