Neuroimaging of Complex Motion in Young and Old Adults
Neuroimaging of Complex Motion in Young and Old Adults
批准号:
6736171
负责人:
Yang Jiang
金额:
$8.65万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-30 至 2006-08-31
关键词:
age difference aging behavior test bioimaging /biomedical imaging brain electrical activity brain imaging /visualization /scanning brain mapping clinical research cognition epidemiology form /pattern perception functional magnetic resonance imaging human old age (65+) human subject motion perception neural information processing neurosciences postdoctoral investigator visual feedback young adult human (21-34)
中文摘要
描述(由申请人提供): 长期职业目标
候选人将在认知领域做出重大科学发现
神经科学并应用研究成果来改善健康和
老龄化人口的流动性。近期的职业目标是成为
参与前沿研究的独立研究员
人类认知衰老的神经影像学。候选人有过去的研究
认知神经科学方面的经验,但需要进一步接受认知衰老方面的培训
衰老的理论和神经影像学方法对于让她能够
实现她的职业目标。 候选人将与导师 Raja 一起工作
Parasuraman 在认知神经科学和衰老方面拥有丰富的专业知识
以及谁在这些领域培训学生和研究员方面拥有良好的记录。
培训环境将包括认知领域顶尖研究人员团队
衰老、神经科学和神经影像学。该小组将提供以下方面的培训:
认知和神经影像涉及的理论问题和分析方法
对老参与者的研究,以及涉及的问题
年轻人和老年人之间的神经影像数据的比较。 K01奖
将为候选人提供必要的时间和支持来为她奉献
作为认知衰老领域的独立研究员研究职业发展
和认知神经科学。在她的研究计划中,候选人将检查
人脑如何处理有关复杂运动的视觉信息(例如,
运动形状),以及哪些皮质机制介导与年龄相关的变化
在复杂的运动感知中。这个话题很重要,因为很多日常生活
老年人执行的任务,例如步行、驾驶和玩耍
运动,严重依赖于复杂视觉运动的处理
大脑。目的是确定人类皮质的表征
由年轻人和老年人的运动定义的表面和物体,使用两者
行为方法和功能磁共振成像(fMRI)。的
中心假设是识别相对运动物体的缺陷
老年时是由于特定功能效率的变化
大脑的皮质区域。另外复杂的运动处理是
由简单运动处理区域之外的皮质区域介导
人类视觉皮层。具体来说,拟议的研究将(1)确定
与运动定义的平面和运动处理相关的人类皮质区域
深度弯曲表面; (2) 识别调节的皮质区域
使用注意力调制处理运动形状; (3) 确定
与年龄相关的视觉处理能力下降的神经基础
有关复杂运动的信息。行为学和神经影像学的结合
方法将导致成功建立之间的因果关系
年轻人的视觉运动处理和皮质功能(或功能障碍)
和旧的。这将为进一步发展奠定基础
解决重要健康和流动问题的诊断和治疗工具
老年人的问题。
英文摘要
DESCRIPTION (Provided by applicant): The long-term career goal of the
candidate is to make significant scientific discoveries in cognitive
neuroscience and to apply research findings to improving the health and
mobility of the aging population. The immediate career objective is to become
an independent researcher involved in cutting-edge research in the
neuroimaging of human cognitive aging. The candidate has past research
experience in cognitive neuroscience, but further training in cognitive aging
theories and neuroimaging methods in aging are necessary to allow her to
attain her career goals. The candidate will work with a mentor, Raja
Parasuraman who has extensive expertise in cognitive neuroscience and aging
and who has a proven record of training students and fellows in these fields.
The training environment will involve a team of top researchers in cognitive
aging, neuroscience, and neuroimaging. This group will provide training in the
theoretical issues and analysis methods involved in cognitive and neuroimaging
studies in old participants, as well as in the issues involved in the
comparison of neuroimaging data between young and old adults. The K01 award
will allow the candidate the time and support necessary to devote to her
research career development as an independent researcher in cognitive aging
and cognitive neuroscience. In her research plan, the candidate will examine
how the human brain processes visual information about complex motion (e.g.,
shape-from-motion), and what cortical mechanisms mediate age-related changes
in complex motion perception. The topic is important because many everyday
tasks carried out by older adults, such as walking, driving, and playing
sports, are critically dependent on the processing of complex visual motion by
the brain. The objective is to identify the human cortical representation of
surfaces and objects defined by motion in young and old adults, using both
behavioral methods and functional magnetic resonance imaging (fMRI). The
central hypothesis is that deficits in recognizing objects in relative motion
in old age are due to changes in the functional efficiency of specific
cortical areas in the brain. Additionally complex motion processing is
mediated by cortical regions beyond the simple motion processing areas in the
human visual cortex. Specifically, the proposed studies will (1)identify the
human cortical areas associated with the processing of motion-defined flat and
curved surfaces in depth; (2) identify the cortical areas mediating the
processing of shape-from-motion using attention modulation; and (3) determine
the neural basis of age-related decreases in ability to process visual
information about complex motion. Combination of behavioral and neuroimaging
methods will lead to successful establishment of causal relationships between
visual motion processing and cortical function (or dysfunction) in the young
and old. This will provide a foundation for the further development of
diagnostic and therapeutic tools to address important health and mobility
problems in the elderly.
期刊论文(0)
专著(0)
科研奖励(0)
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批准号:6937265
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资助金额:$12.26万
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批准号:6649217
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批准号:6370832
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资助金额:$10.26万
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资助金额:$2.66万
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财政年份:2001
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负责人:Yang Jiang
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依托单位:
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负责人:Yang Jiang
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依托单位:
海外基金