Physical Activity, Aging and Immune Function

体力活动、衰老和免疫功能

• 批准号: 6623600
• 负责人: JEFFREY Adam WOODS
• 金额: $ 42.99万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6623600
• 关键词: aerobic exercise; aging; antibody formation; antibody titering; blood tests; clinical trials; delayed hypersensitivity; developmental immunology; epidemiology; evaluation /testing; human old age (65+); human subject; immunoregulation; influenza vaccines; longitudinal human study; patient oriented research; quality of life; social psychology; tetanus toxoid

The extent to which exercise training or long-term physical activity influences dysregulated immune function in the elderly is unclear. Preliminary evidence suggests that exercise training may improve various dysregulated immune function measures in older adults. Although such findings have the potential to be of substantial public health importance, the majority of studies have suffered from small sample sizes, inadequate measurement of physical fitness, and weak research designs. .The proposed study is designed to overcome these limitations by employing a longitudinal randomized controlled trial examining the effect of exercise training on clinically relevant immune function measures in older adults (65-80 years). Moreover, relationships between several factors known to be altered by exercise training and changes in immune function will be assessed. As such, there are two specific aims to be addressed. In Aim 1, a one-year exercise trial is proposed to determine whether moderate intensity aerobic exercise training can improve immune function in previously sedentary older adults. In Aim 2, the role played by physiological, behavioral, and psychosocial factors in the relationship between exercise training and improved immune function will be examined. Employing a randomized controlled trial, sedentary subjects (n=150) will be randomly assigned to either a one year moderate aerobic exercise training program (n = 75) or a sedentary control group (n = 75). Clinically relevant measures of immune function including the delayed-type hypersensitivity response to a battery of antigens and the antibody response to tetanus toxoid and influenza virus vaccination will be assessed before, during and after the intervention. We hypothesize that exercise training will result in improved immune responses including higher peak antibody titers and DTH responses, and sustained levels of protective antibodies. State-of-the-art analytical methods using multiple imputation and latent growth curve analyses will allow us to determine the growth and form of immune function parameters over the study period and the relative role played by physiological, behavioral, and psychosocial variables in this growth. Findings from the proposed study will help determine the role played by exercise training in immune functioning in the elderly thereby providing important empirical evidence to substantiate the prescription of exercise to combat disease and dysfunction. The public health yield of such information is likely to be substantial. In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function.

运动训练或长期体育锻炼影响老年人的免疫功能失调的程度尚不清楚。初步证据表明，运动训练可能会改善老年人的各种失调的免疫功能度量。尽管这样的发现有可能具有很大的公共健康重要性，但大多数研究都遭受了较小的样本量，身体健康的测量不足和研究设计薄弱。拟议的研究旨在通过采用纵向随机对照试验来克服这些局限性，该试验研究了运动训练对老年人临床相关免疫功能测量的影响（65 - 80年）。此外，将评估已知已知的几个因素之间的关系，将通过运动训练改变与免疫功能的变化。因此，有两个具体的目标要解决。在AIM 1中，提出了一年的运动试验，以确定中等强度的有氧运动训练是否可以改善以前久坐的老年人的免疫功能。在AIM 2中，将检查生理，行为和心理社会因素在运动训练与改善免疫功能之间的关系中所起的作用。使用随机对照试验，久坐的受试者（n = 150）将随机分配给一年中等有氧运动训练计划（n = 75）或久坐的对照组（n = 75）。免疫功能的临床相关度量包括对一组抗原的延迟类型的超敏反应以及对破伤风毒素和流感病毒疫苗的抗体反应，将在干预之前，之中和之后进行评估。我们假设运动训练将改善免疫反应，包括较高的峰值抗体滴度和DTH反应，以及持续的保护性抗体水平。使用多个插补和潜在生长曲线分析的最先进的分析方法将使我们能够在研究期间确定免疫功能参数的生长和形式，以及在这种增长中生理，行为和心理社会变量所起的相对作用。拟议的研究的发现将有助于确定运动训练在老年人中的免疫功能中所起的作用，从而提供重要的经验证据，以证实锻炼处方以打击疾病和功能障碍。此类信息的公共卫生产量可能很大。此外，我们目标固有的生物行为方法将使我们能够确定运动与免疫功能之间关系的复杂性。