Sleep During the Perimenopause in a Multi-Ethnic Cohort

这项互动研究项目资助（IRPG）将描述430名妇女的更年期特征和睡眠之间的关系：200名白人，150名非洲裔美国人和80名中国人。 尽管中年女性的睡眠中断、失眠和睡眠呼吸障碍的发生率增加，但人们对更年期和睡眠之间的关系知之甚少。 血管紧张症状和激素替代疗法对睡眠的影响表明，睡眠与更年期的关系不仅仅是年龄的函数。 鉴于睡眠对心理和身体健康的影响，更好地了解中年女性睡眠障碍的原因非常重要。 睡眠障碍与许多负面的健康结果有关，包括生产力和生活质量的损失，精神病发病率，免疫抑制以及对疾病和疾病的易感性增加。 本IRPG的研究目的是：1）描述中年女性大样本、多种族样本中的睡眠障碍; 2）描述绝经特征和睡眠障碍之间的关系; 3）评价相关心理生物学因素对睡眠-绝经关系的影响; 4）为未来的纵向研究建立基线数据。 来自正在进行的全国妇女健康研究（SWAN）的七个研究中心中的四个将合作从SWAN队列中招募绝经前和围绝经期妇女的样本。 一旦入组睡眠研究，受试者将在新的月经周期开始时开始方案。 在方案的第1-3天，将在参与者家中进行动态多导睡眠描记术。 将在整个周期内收集睡眠日记、活动记录仪和血管痉挛症状数据的事件监测记录。 数据还将包括关于绝经特征（出血模式、血管炎症状、激素水平）和相关心理生物学因素的5年核心SWAN研究数据。 回归技术将被用来模拟更年期特征，睡眠和相关的心理生物学因素之间的关系。 匹兹堡研究中心将培训研究人员使用睡眠监测设备，并负责处理、评分和存档所有睡眠数据。 所有睡眠研究数据以及Core SWAN研究的相关数据将由密歇根研究中心合并和分析。 芝加哥和加州大学戴维斯分校的PIS将共同主持睡眠研究指导委员会。

This Interactive Research Project Grant (IRPG) will characterize the relationship between menopausal characteristics and sleep in a sample of 430 women: 200 Caucasian, 150 African- American, and 80 Chinese. Although sleep disruptions, insomnia and the incidence of sleep disordered breathing increase in mid- life women, little is known about the relationship between menopause and sleep. The impact of vasomotor symptoms and hormone replacement therapy on sleep suggests that the sleep- menopause relationship is not merely a function of age. A greater understanding of the causes of sleep disturbances in mid- life women is important, given the impact of sleep on mental and physical health. Sleep disturbances are associated with a host of negative health outcomes including losses in productivity and quality of life, psychiatric morbidity, immunosuppression, and increased vulnerability to illness and disease. The study aims of this IRPG are to: 1) characterize sleep disturbances in a large, multi-ethnic sample of mid-life women; 2) characterize relationships among menopausal characteristics and sleep disturbances; 3) evaluate the influence of relevant psychobiological factors on the sleep-menopause relationship; and 4) establish baseline data for a future longitudinal study. Four of seven study sites from the ongoing Study of Women's Health Across the Nation (SWAN) will collaborate to recruit a sample of pre- and peri-menopausal women from the SWAN cohort. Once enrolled in the Sleep Study, participants will begin the protocol at the start of a new menstrual cycle. Ambulatory polysomnography will be conducted in participants' homes during days 1-3 of the protocol. Sleep diary, actigraphy, and event monitor recordings of vasomotor symptom data will be collected throughout the cycle. Data will also include five years of Core SWAN study data on menopausal characteristics (bleeding patterns, vasomotor symptoms, hormone levels) and related psychobiological factors. Regression techniques will be used to model relationships among menopausal characteristics, sleep, and related psychobiological factors. The Pittsburgh site will train study personnel in the use of sleep monitoring equipment and will be responsible for processing, scoring, and archiving all sleep data. All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC Davis PIS will co-chair the Sleep Study Steering Committee.