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THE ROLE OF GHRELIN DURING AGING

THE ROLE OF GHRELIN DURING AGING
生长素释放肽在衰老过程中的作用
批准号：
6631566
负责人：
ROY G SMITH
金额：
$33.64万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-03-01 至 2005-02-28
来源：
https://reporter.nih.gov/project-details/6631566
关键词：
aging blood brain barrier calcium indicator electrospray ionization mass spectrometry high performance liquid chromatography hormone metabolism hormone receptor hormone regulation /control mechanism hypothalamus laboratory mouse luciferin monooxygenase protein isoforms protein structure function receptor binding reporter genes secretion site directed mutagenesis somatotropin synthetic peptide

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英文摘要
DESCRIPTION: (Adapted from the applicant's abstract) This application addresses a number of questions regarding the activity both endogenous (Ghrelin) and synthetic (GH releasing peptide, GHRPs, such as MK-0677) ligands for the Growth Hormone Secretagogue Receptor (GHS-R) and the nature of their interaction. The application has an overall aim of elucidating the physiologic role of GHS-R, especially as it relates to aging. It is predicated on a significant amount of preliminary data, and driven by a number of hypotheses. Specifically, four aims are proposed: 1) determine the function of the octanoyl moiety on Ghrelin and its role in Ghrelin's interaction with the GHS-R, 2) using site directed mutagenesis, determine the characteristics of the GHS-R binding pocket(s) that interact with Ghrelin, a putative truncated Ghrelin 1-14, and synthetic GHRPs, 3) Determine whether Ghrelin and its potential alternate forms stimulate activity in hypothalamic neuron and define the hypothalamic neurons that respond to these ligands and, 4) determine whether aging is associated with a decline in Ghrelin activity; then whether such a putative decline is due to a decrease in Ghrelin acylating activity.
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