Epigenetic regulation of L1 retrotransposition in mouse models of abnormal human neurobiology

异常人类神经生物学小鼠模型中 L1 逆转录转座的表观遗传调控

• 批准号: nhmrc : 1045991
• 负责人: Dr Kyle Upton
• 金额: $ 27.86万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-l1-human-neurobiology/111806
• 关键词: Epigenetic; regulation; L1; retrotransposition; mouse

Retrotransposons are mobile genes that copy-and-paste themselves to spread in DNA. Until very recently, they were thought to only be active in sperm and egg. In our recent work, we demonstrated that they also move in the brain. In the current study, we will use cutting-edge technologies to determine how retrotransposons change the genetic makeup of neurons in neurodevelopmentally impaired mice to predict whether these mutations would also be present in human brain disorders.

逆转录转座子是可移动的基因，可以自我复制并粘贴以在 DNA 中传播。直到最近，它们还被认为只在精子和卵子中活跃。在我们最近的工作中，我们证明它们也在大脑中移动。在当前的研究中，我们将利用尖端技术来确定逆转录转座子如何改变神经发育受损小鼠神经元的基因组成，以预测这些突变是否也存在于人类大脑疾病中。