A three-tiered strategy to prevent destabilisation of the induced pluripotent stem cell genome by L1 retrotransposition

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Retrotransposons are mobile genes that copy-and-paste themselves in our genome. Previously thought to represent “junk DNA”, retrotransposons are increasingly recognised to play major roles in biology. In recent publications in Cell and Nature, we found that retrotransposons move in mature human cells. In the current study, we will determine whether the same activity occurs when these cells are reprogrammed to become stem cells, possibly impacting stem cell based therapies.