New Drugs from Marine Natural Resources--Jamaican Reefs

来自海洋自然资源的新药物——牙买加珊瑚礁

• 批准号: 6720023
• 负责人: LARRY A WALKER
• 金额: $ 17.3万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6720023
• 关键词: Caribbean islands; antiinfective agents; antineoplastics; biological products; clinical research; coral; drug discovery /isolation; ecology; international cooperation; marine biology; training

DESCRIPTION (provided by applicant): This planning grant is submitted in anticipation of a comprehensive ICBG effort in 2005. The comprehensive program aims are: 1) to discover marine natural products from Jamaican reefs as prototypes for the development of new therapies for cancer and infectious diseases, 2) to develop biological and chemical data relative to ecological factors in support of conservation/restoration efforts, and 3) to contribute to sustainable economic development and scientific/technological enrichment in Jamaica. This strategy will rely on a concerted multi-disciplinary, multi-institutional research effort of three associate programs, an administrative core, and a biological-testing core. Recent studies of marine natural products indicate that coral reefs represent one of the greatest resources for bio-, and chemo-diversity. Jamaica represents a biodiversity hotspot of many important coral reef organisms in the Caribbean, including algae and sponges, which have traditionally produced the greatest marine natural product diversity/bioactivity. While Jamaican reefs have been impacted by competing anthropogenic interests (e.g., fisheries, tourism, coastal development), they are recovering and ICBG-related conservation efforts will further spur the regeneration of these important coral reef systems. A successful ICBG application will require MOU's and MTA's between the University of Mississippi and the host country collaborator(s), a collection agreement with the cognizant government agency, and prior informed consent of local stakeholders. Thus, the aim of this planning grant is to consolidate appropriate partnerships and agreements, develop an operating framework and a detailed research plan, and generate preliminary biodiversity/ecological survey data requisite for success in the integrated core areas of the ICBG program. Our ICBG team includes expertise in biodiversity assessments, marine ecology & mariculture, marine microbiology, marine natural products isolation/structure elucidation, bioassay development, technology transfer/IP issues, and the design/analysis of social science surveys. These individuals are committed to providing meaningful transfer of training and technology to host country stakeholders in support of short- and long-term shared benefits. Significantly, this ICBG program recognizes the potential fragility of tropical marine resources and has thus incorporated mechanisms to develop sustainable resource practices (including mariculture, microbe culture, and defense induction) for harvesting important biomedical and/or biotechnological products. This planning grant will promote awareness of human health issues, biodiversity conservation, marine natural resource utilization, and biomedical/biotechnological training to Jamaican, and US, scientists collaborating in support of socioeconomic opportunities and human/environmental health for host country stakeholders.

描述（由申请人提供）：这项规划赠款是在2005年ICBG全面努力的预期下提交的。该综合方案的目标是：1）从牙买加珊瑚礁中发现海洋天然产品，作为开发癌症和传染病新疗法的原型，2）开发与生态因素有关的生物和化学数据，以支持保护/恢复工作，3）促进牙买加的可持续经济发展和科学/技术丰富。这一战略将依赖于三个副计划，一个行政核心和一个生物测试核心的协调一致的多学科，多机构的研究工作。最近对海洋天然产品的研究表明，珊瑚礁是生物和化学多样性的最大资源之一。牙买加是生物多样性的热点 在加勒比地区，珊瑚礁是许多重要的珊瑚礁生物体的重要组成部分，包括藻类和海绵，它们历来是最大的海洋天然产品多样性/生物活性来源。虽然牙买加珊瑚礁受到相互竞争的人类利益的影响（例如，这些珊瑚礁正在恢复，与国际珊瑚礁小组有关的保护工作将进一步刺激这些重要的珊瑚礁系统的再生。 成功的ICBG申请将需要密西西比大学和东道国合作者之间的谅解备忘录和MTA，与政府机构的收集协议，以及当地利益相关者的事先知情同意。因此，这项规划赠款的目的是巩固适当的伙伴关系和协议，制定一个运作框架和详细的研究计划，并产生初步的生物多样性/生态调查数据，在ICBG计划的综合核心领域取得成功所必需的。我们的ICBG团队包括生物多样性评估、海洋生态学和海水养殖、海洋微生物学、海洋天然产物分离/结构解析、生物测定开发、技术转让/知识产权问题以及社会科学调查的设计/分析方面的专业知识。这些人致力于向东道国利益攸关方提供有意义的培训和技术转让，以支持短期和长期的利益共享。重要的是，ICBG计划认识到热带海洋资源的潜在脆弱性，因此纳入了开发可持续资源做法的机制 （包括海产养殖、微生物培养和防御诱导）用于收获重要的生物医学和/或生物技术产品。这项规划赠款将促进对人类健康问题、生物多样性保护、海洋自然资源利用的认识，并为牙买加和美国科学家提供生物医学/生物技术培训，以支持东道国利益攸关方的社会经济机会和人类/环境健康。