Histopathology and Electroretinography Services
组织病理学和视网膜电图服务
基本信息
- 批准号:6650941
- 负责人:
- 金额:$ 25.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-04-01 至 2008-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Study of a clinical phenotype is important both for identifying affected mice and also to detect progressive changes with age. At all stages of disease development, histopathologic analysis is a critical research component for determination of precise physical changes, correlation with functional changes, and localization of gene and protein expression. The Jackson Laboratory (TJL) eye investigators use diverse sophisticated histological techniques to obtain accurate, informative data on eye morphology and histopathology. However, continued expansion of eye research at TJL has created a demand for histology services that is straining the capacity of TJL's resources to provide these services, preventing further growth of the Laboratory's eye research programs. The proposed Histology Module will provide a skilled histologist dedicated to the support of eye research at TJL, and additional histology equipment, ensuring that the histology needs of the eye group are met and allowing continued research growth. Electroretinographic (ERG) analysis is also an essential component of eye research at TJL, because of its ability to identify and characterize functional abnormalities indicative of ocular disorders. ERG analysis at TJL is currently performed in the Eye Mutant Resource, a program to identify, characterize, and map mouse eye mutations and is a critical component of that program. However, the significant recent expansion of TJL's individual eye research programs, together with increased screening needs of the Eye Mutant Resource and other large-scale TJL programs, have created a demand for ERG testing that cannot be met by existing resources. This in turn hinders continued progress in eye research at TJL. The proposed ERG Module will provide a research assistant dedicated to performing ERG analyses for ocular research projects, using ERG equipment recently purchased by TJL. This will ensure the continued expansion of the eye research programs of individual TJL investigators and will also support screening for ocular disorders in other programs at TJL. It is anticipated that both the histology and ERG modules will help attract new scientists to eye research.
描述(由申请人提供):对临床表型的研究对于识别受影响的小鼠和检测随年龄的渐进性变化都很重要。在疾病发展的所有阶段,组织病理学分析是确定精确的生理变化、与功能变化的相关性以及基因和蛋白质表达定位的关键研究组成部分。杰克逊实验室(TJL)的眼睛研究人员使用各种复杂的组织学技术来获得关于眼睛形态和组织病理学的准确、信息丰富的数据。然而,TJL眼科研究的持续扩展产生了对组织学服务的需求,这使得TJL提供这些服务的资源能力变得紧张,阻碍了实验室眼科研究项目的进一步增长。拟议的组织学模块将提供一名熟练的组织学家,致力于支持TJL的眼部研究,并提供额外的组织学设备,确保满足眼科组的组织学需求,并使研究持续增长。视网膜电信号(ERG)分析也是TJL眼科研究的重要组成部分,因为它能够识别和表征指示眼部疾病的功能异常。TJL的ERG分析目前在眼突变资源中进行,这是一个识别、表征和定位小鼠眼睛突变的计划,是该计划的关键组成部分。然而,TJL的个人眼睛研究项目最近显著扩大,加上眼部突变资源和其他大规模TJL项目的筛查需求增加,产生了现有资源无法满足的ERG测试需求。这反过来又阻碍了TJL眼科研究的持续进展。拟议的ERG模块将使用TJL最近购买的ERG设备,提供专门用于眼科研究项目的ERG分析的研究助理。这将确保TJL研究人员个人的眼科研究项目继续扩大,并将支持TJL其他项目中的眼部疾病筛查。预计组织学和ERG模块都将有助于吸引新的科学家进行眼科研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RICHARD S SMITH其他文献
RICHARD S SMITH的其他文献
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{{ truncateString('RICHARD S SMITH', 18)}}的其他基金
Histopathology and Electroretinography Services
组织病理学和视网膜电图服务
- 批准号:
7039014 - 财政年份:2003
- 资助金额:
$ 25.56万 - 项目类别:
Histopathology and Electroretinography Services
组织病理学和视网膜电图服务
- 批准号:
6717633 - 财政年份:2003
- 资助金额:
$ 25.56万 - 项目类别:
Histopathology and Electroretinography Services
组织病理学和视网膜电图服务
- 批准号:
6867332 - 财政年份:2003
- 资助金额:
$ 25.56万 - 项目类别:
Histopathology and Electroretinography Services
组织病理学和视网膜电图服务
- 批准号:
7189106 - 财政年份:2003
- 资助金额:
$ 25.56万 - 项目类别:
EPITHELIAL AND ENDOTHELIAL PROLIFERATION IN CORN1 MICE
CORN1 小鼠的上皮和内皮增殖
- 批准号:
6125141 - 财政年份:1998
- 资助金额:
$ 25.56万 - 项目类别:
EPITHELIAL AND ENDOTHELIAL PROLIFERATION IN CORN1 MICE
CORN1 小鼠的上皮和内皮增殖
- 批准号:
6329563 - 财政年份:1998
- 资助金额:
$ 25.56万 - 项目类别:
EPITHELIAL AND ENDOTHELIAL PROLIFERATION IN CORN1 MICE
CORN1 小鼠的上皮和内皮增殖
- 批准号:
6476410 - 财政年份:1998
- 资助金额:
$ 25.56万 - 项目类别:
EPITHELIAL AND ENDOTHELIAL PROLIFERATION IN CORN1 MICE
CORN1 小鼠的上皮和内皮增殖
- 批准号:
2763553 - 财政年份:1998
- 资助金额:
$ 25.56万 - 项目类别:
MORPHOLOGIC, DEVELOPMENTAL & GENETIC ASPECTS OF CATARACTS IN TRISOMY 4/17 MICE
形态、发育
- 批准号:
6253953 - 财政年份:1997
- 资助金额:
$ 25.56万 - 项目类别: