HP/MICROSCOPY

惠普/显微镜

• 批准号: 8476495
• 负责人: RICHARD S SMITH
• 金额: $ 33.08万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8476495
• 关键词: Autopsy; Biological; Biophysics; Cancer Center; Cancer Center Support Grant; Chromosomes; Computer-Assisted Image Analysis; Confocal Microscopy; Consult; Cytogenetics; Disease; Electron Microscopy; Ensure; Faculty; Fee-for-Service Plans; Fluorescence; Fluorescent in Situ Hybridization; Funding; Grant; Histology; Histopathology; Image; Image Analysis; Immunofluorescence Immunologic; In Situ Hybridization; Institutes; Karyotype determination procedure; Label; Laboratories; Life; Microscopy; Molecular; Mus; Normal tissue morphology; Pathologist; Pathology; Preparation; Procedures; Research; Research Infrastructure; Sampling; Scanning Electron Microscopy; Schedule; Science; Scientist; Services; Staining method; Stains; Support System; Technology; Time; Tissue Banks; cellular imaging; computerized; cost effective; experience; follow-up; functional genomics; imaging probe; laser capture microdissection; light microscopy; meetings; member; mutant; operation; tissue processing

The Histopathology & Microscopy Sciences (HPMS) Service offers Cancer Center members access to technologies and expertise in Histology, Necropsy, Electron Microscopy (scanning and electron), Light Microscopy and Cytogenetics. In combination with the Institute for Molecular Biophysics, HPMS delivers Cancer Center faculty unparalleled access to leading edge microscopy systems and the supporting infrastructure needed for the analysis and characterization of normal tissue morphology and mutant disease pathologies. Through HPMS Cancer Center, members access mouse necropsy, tissue collection, routine and specialized tissue processing and histological stains, immunofluorescence labeling, in situ hybridization, confocal microscopy, multiphoton microscopy, live-cell imaging, fluorescence and standard light microscopy, laser capture microdissection (LCM), computerized image analysis, and karyotyping and fluorescent in situ hybridization for chromosome analysis. HPMS (formerly Biological Imaging) has been supported by the CCSG grant for the past five years. The HPMS Project Leader, Research Scientist Dr. Richard Smith, oversees this fee-for-service operation. To further support the pathology analysis needs of the Cancer Center, access to Dr. Bronson, the Center's consulting Pathologist, and to all recommended follow-up procedures, are scheduled through HPMS. Six full-time histologists, two microscopists, three necropsy technicians, a cytogeneticist, consulting pathologist and senior manager staff the facility which occupies 3,772 ft2 of laboratory space in the Functional Genomics Building. Dr. Smith communicates with the Cancer Center users, Service staff and Center Administration to ensure that research needs are met in the most efficient, cost-effective and technically current manner.

组织学和显微镜科学（HPMS）服务为癌症中心成员提供访问 组织学、尸检、电子显微镜（扫描和电子）、光 显微镜和细胞遗传学。HPMS与分子生物物理研究所合作， 癌症中心教师无与伦比的访问领先的显微镜系统和支持 正常组织形态和突变体的分析和表征所需的基础设施 疾病病理学通过HPMS癌症中心，成员可以访问小鼠尸检，组织 采集、常规和专门的组织处理和组织学染色、免疫荧光 标记，原位杂交，共聚焦显微镜，多光子显微镜，活细胞成像， 荧光和标准光显微镜，激光捕获显微切割（LCM），计算机图像 染色体分析，核型分析和荧光原位杂交进行染色体分析。HPMS（原 生物成像）在过去五年中一直得到CCSG赠款的支持。HPMS项目 领导者，研究科学家理查德·史密斯博士，监督这项收费服务的运作。进一步支持 癌症中心的病理分析需求，获得布朗森博士，该中心的咨询 通过HPMS安排病理学家和所有推荐的随访程序。6个全职 组织学家、两名显微镜学家、三名尸检技术员、一名细胞遗传学家、病理学家顾问和 功能基因组学实验室占地3，772平方英尺， 建设史密斯博士与癌症中心用户、服务人员和中心管理人员进行沟通 确保以最有效、最具成本效益和技术最先进的方式满足研究需求。