How does the plant regulate receptor signaling to balance immune response and growth?

植物通过检测病原体相关分子模式(PAMP)来感知微生物，这是由细胞表面定位的模式识别受体(PRR)介导的。对PAMPs的感知触发了一个信号网络，其中包括丝裂原激活蛋白激酶(MAPK)的激活，防御基因表达的激活，最终导致PAMP触发的免疫(PTI)。对PAMPs的感知也会导致生长抑制，主要是通过未知的信号事件。由于生长的调节也涉及受体介导的对植物多肽的感知，因此存在交叉调节的可能性。已经确定了一些连接，表明PRR信号和植物多肽信号之间的一些信号成分是共享的，例如在辅助受体BAK1(1)。此外，最近对植物多肽的感知也与防御反应的负调控有关，并抑制了对微生物病原体的抗性(2，3)。目前的项目研究PRR信号和控制生长的植物多肽信号之间的联系。在目前的项目中，将使用先进的蛋白质组学方法和细胞生物学(使用共聚焦显微镜)来研究基于受体的信号事件。该项目还将涉及分子生物学和蛋白质生物化学，以便对候选人进行广泛的培训。

Plants sense microbial pathogens through the detection of pathogen associated molecular patterns (PAMP) and this is mediated by cell surface localised pattern recognition receptors (PRR). Perception of PAMPs triggers a signaling network that includes activation of mitogen activated protein kinases (MAPK), activation of defence gene expression and ultimately leads to PAMP triggered immunity (PTI). Perception of PAMPs also leads to growth inhibition, by mostly unknown signaling events. Since the regulation of growth also involves receptor-mediated perception of plant peptides there is potential for cross regulation. Some connections have already been identified that suggest some of the signaling components are shared between PRR signaling and plant peptide signaling, such at co-receptor BAK1 (1). Furthermore, perception of plant peptides has recently also been linked to negative regulation of defense response and suppresses resistance to microbial pathogens (2,3). The current project investigates the links between PRR signaling and plant peptide signaling controlling growth. In the current project the receptor based signaling event will be studied with advanced proteomics approaches and cell biology (using confocal microscopy). The project will also involve molecular biology and protein biochemistry allowing for a broad training of the candidate.