The Identity/Role of IP3 Receptor Associated Proteins

描述(由申请人提供)： 神经递质的囊泡运输，神经元对一氧化氮的反应， 和SOCaE是神经元中的关键功能。InsP3-R可能是一个至关重要的 这些过程的调节器(见第30b节)。InsP3-R的结合伙伴 我们发现的可能会调节这种监管的基因。这一领域的最新工作是 证明InsP3-R是许多钙信号转导的中心实体 神经系统中的通路。微生物的微环境鉴定 InsP3-R所在的蛋白质将进一步加深我们对InsP3-R的了解， 以及它的结合伙伴参与神经元信号通路。 此外，它还将增加我们对InsP3-R如何能够 区分汇聚在其活动上的许多路径。 这项建议的主要目标是审查InsP3-R的作用和 神经元中的InsP3-R信号通路。具体地说，我打算确定 InsP3-R的结合伙伴，并研究它们在神经递质中的作用 InsP3-R自身的分泌、SOCaE和调节。

DESCRIPTION (provided by applicant): Vesicle trafficking of neurotransmitters, neuronal response to nitric oxide, and SOCaE are critical functions in neurons. The InsP3-R may be a crucial regulator of these processes (see sec 30b). Binding partners of the InsP3-R that we identify may modulate such regulation. Recent work in this field has demonstrated that the InsP3-R is a central entity in many Ca2+ signaling pathways in neuronal systems. Identification of the microenvironment of proteins in which the InsP3-R resides will further our knowledge of InsP3-R, and its binding partners involvement within in neuronal signaling pathways. Additionally it will increase our knowledge of how the InsP3-R is able to discriminate between the many pathways that converge on its activity. The main objective of this proposal is to examine the role of the InsP3-R and InsP3-R signaling pathways in neurons. Specifically I intend to identify binding partners for the InsP3-R, and examine their roles in neurotransmitter secretion, SOCaE, and regulation of the InsP3-R itself.