Epigenetic therapies as molecular probes to investigate the molecular pathogenesis of leukaemia

表观遗传疗法作为分子探针研究白血病的分子发病机制

• 批准号: nhmrc : 1106444
• 负责人: Prof Mark Dawson
• 金额: $ 64.69万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-therapies-molecular-pathogenesis-leukaemia/662909
• 关键词: Epigenetic; therapies; molecular; probes; investigate

A major limitation to the success of targeted therapies in cancer is the fact that we have few if any tools to study in detail their mechanism of action within cancerous and normal cells. If we were able to visualise these drugs within cells and precisely characterise the proteins, DNA and RNA within a cell that interact with these therapies we will be able to identify strategies that can optimise their efficacy and reduce the side-effects of these treatments.

癌症靶向治疗成功的一个主要限制是，我们几乎没有任何工具来详细研究它们在癌细胞和正常细胞中的作用机制。如果我们能够在细胞内可视化这些药物，并精确地识别细胞内与这些疗法相互作用的蛋白质，DNA和RNA，我们将能够确定可以优化其疗效并减少这些治疗副作用的策略。