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Epigenetic therapies as molecular probes to investigate the molecular pathogenesis of leukaemia

Epigenetic therapies as molecular probes to investigate the molecular pathogenesis of leukaemia
表观遗传疗法作为分子探针研究白血病的分子发病机制
批准号：
nhmrc : 1106444
负责人：
Prof Mark Dawson
金额：
$64.69万
依托单位：
The University of Melbourne
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2016
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2016-01-01 至 2020-12-31
来源：
https://researchdata.edu.au/epigenetic-therapies-molecular-pathogenesis-leukaemia/662909
关键词：
Epigenetictherapiesmolecularprobesinvestigate

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中文摘要
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英文摘要
A major limitation to the success of targeted therapies in cancer is the fact that we have few if any tools to study in detail their mechanism of action within cancerous and normal cells. If we were able to visualise these drugs within cells and precisely characterise the proteins, DNA and RNA within a cell that interact with these therapies we will be able to identify strategies that can optimise their efficacy and reduce the side-effects of these treatments.
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Understanding co-activator function in transcriptional regulation
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  • 项目类别：
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Epigenetic regulation of self renewal and lineage commitment in haematopoiesis
  • 批准号：
    nhmrc : GNT1106447
  • 项目类别：
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    2016
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    nhmrc : 1085015
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国内基金
海外基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data