Epigenetic regulation of self renewal and lineage commitment in haematopoiesis

造血过程中自我更新和谱系定型的表观遗传调控

• 批准号: nhmrc : 1106447
• 负责人: Prof Mark Dawson
• 金额: $ 76.49万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-self-commitment-haematopoiesis/662910
• 关键词: Epigenetic; regulation; self; renewal; lineage

The process by which all our mature blood cells are produced and sustained remains largely unknown. Underpinning the cell fate decisions made through blood cell development is the tightly regulated expression of key genes and proteins that subsequently direct the process of blood cell differentiation. This project will aim study and uncover the molecular mechanisms that coordinate the key gene expression programs that lead to normal blood cell development.

我们所有的成熟血细胞产生和维持的过程在很大程度上仍然是未知的。通过血细胞发育做出的细胞命运决定的基础是关键基因和蛋白质的严格调控表达，这些基因和蛋白质随后指导着血细胞分化的过程。该项目将致力于研究和揭示协调导致血细胞正常发育的关键基因表达程序的分子机制。