Discrimination of object orientation by visual cortex

视觉皮层对物体方向的辨别

• 批准号: 6622454
• 负责人: JULIANNE E ROLLENHAGEN
• 金额: $ 2.89万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6622454
• 关键词: Macaca; behavioral /social science research tag; discrimination learning; electrical measurement; form /pattern perception; neural information processing; neurons; neurophysiology; neuropsychology; orientation; parietal lobe /cortex; predoctoral investigator; temporal lobe /cortex; visual perception

DESCRIPTION (provided by applicant): The goal of the proposed studies is to characterize the role of the inferotemporal cortex and parietal cortex (area LIP) in the discrimination of object orientation. It has been shown in animal studies that lesions of the temporal cortex, while disrupting the ability to discriminate among different objects, leave intact the ability to discriminate among different orientations of the same object. Conversely, lesions of parietal cortex impair object orientation discrimination but spare object recognition. Parallel results have been obtained in clinical studies of humans. Thus it seems reasonable to hypothesize that the discrimination of object orientation involves primarily parietal and not inferotemporal (IT) cortex. To test this hypothesis, we will record the activity of neurons in IT and area LIP of the macaque monkey during the performance of fixation and object orientation discrimination tasks. Monkeys will be initially trained to discriminate between different orientations of ten objects. Following training, neural activity in IT and LIP will be collected using extracellular electrophysiological recording techniques. The data will be analyzed to test two predictions: (a) that neurons in LIP are more selective for object orientation than neurons in IT and (b) that neuronal activity in LIP is better correlated with the monkey?s orientation discrimination performance than neuronal activity in IT. The results of these studies will elucidate the manner in which object orientation is encode in the brain and provide insight into the nature of processes impaired following parietal lobe injury.

描述（由申请人提供）：拟议研究的目标是