Discrimination of object orientation by visual cortex

视觉皮层对物体方向的辨别

• 批准号: 6446523
• 负责人: JULIANNE E ROLLENHAGEN
• 金额: $ 3.55万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6446523
• 关键词: Macaca; behavioral /social science research tag; discrimination learning; electrical measurement; form /pattern perception; neural information processing; neurons; neurophysiology; neuropsychology; orientation; parietal lobe /cortex; predoctoral investigator; temporal lobe /cortex; visual perception

DESCRIPTION (provided by applicant): The goal of the proposed studies is to characterize the role of the inferotemporal cortex and parietal cortex (area LIP) in the discrimination of object orientation. It has been shown in animal studies that lesions of the temporal cortex, while disrupting the ability to discriminate among different objects, leave intact the ability to discriminate among different orientations of the same object. Conversely, lesions of parietal cortex impair object orientation discrimination but spare object recognition. Parallel results have been obtained in clinical studies of humans. Thus it seems reasonable to hypothesize that the discrimination of object orientation involves primarily parietal and not inferotemporal (IT) cortex. To test this hypothesis, we will record the activity of neurons in IT and area LIP of the macaque monkey during the performance of fixation and object orientation discrimination tasks. Monkeys will be initially trained to discriminate between different orientations of ten objects. Following training, neural activity in IT and LIP will be collected using extracellular electrophysiological recording techniques. The data will be analyzed to test two predictions: (a) that neurons in LIP are more selective for object orientation than neurons in IT and (b) that neuronal activity in LIP is better correlated with the monkey?s orientation discrimination performance than neuronal activity in IT. The results of these studies will elucidate the manner in which object orientation is encode in the brain and provide insight into the nature of processes impaired following parietal lobe injury.

描述(由申请人提供)：建议研究的目标是 描述颞下皮质和顶叶皮质(区域)的作用 唇语)在辨别客体指向中的作用。它已经在动物身上显示出来了。 研究表明，颞叶皮质的损伤，同时扰乱了 区分不同的对象，保持不变的区分能力 在同一物体的不同方向之间。相反，脑部损伤 顶叶皮质削弱物体定向辨别能力，但保留物体 承认。在人类的临床研究中也得到了类似的结果。 因此，假设对客体的歧视似乎是合理的 定位主要涉及顶叶皮质，而不是颞下(IT)皮质。至 验证这一假设，我们将记录IT区和唇区神经元的活动 猕猴在注视和物体定向过程中的表现 辨别任务。猴子将在最初的训练中区分 十个物体的不同方位。训练后，神经活动在 它和LIP将使用细胞外电生理记录进行收集 技巧。将对数据进行分析，以检验两种预测：(A)神经元 嘴唇中神经元比信息技术中的神经元对物体定向更具选择性 嘴唇中的神经元活动与猴子S的相关性更好 IT中方位辨别能力强于神经元活动。这个 这些研究的结果将阐明对象定向的方式 在大脑中进行编码，并提供对过程本质的洞察 顶叶损伤后受损。