PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II

肺栓塞 DX-II 的前瞻性研究

• 批准号: 6527264
• 负责人: Pamela K Woodard
• 金额: $ 29.18万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6527264
• 关键词: angiography; bioimaging /biomedical imaging; clinical research; computed axial tomography; cooperative study; diagnosis design /evaluation; human subject; lung imaging /visualization /scanning; noninvasive diagnosis; pulmonary circulation obstruction; ultrasonography; venous thrombosis

(Adapted from the applicant's abstract) This is a multicenter collaborative study to determine the sensitivity, specificity, positive and negative predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal. Spiral CT is a nearly noninvasive test that offers the possibility of a definitive diagnosis of PE by showing the outline of the thrombus in a pulmonary artery. However, its utility in the diagnosis of PE is unknown. Even though spiral CT has not been adequately validated, physicians at many hospitals now use it as a definitive and only diagnostic test. This could lead to overtreatment or undertreatment, both of which have serious potential complications. The role of spiral CT in the diagnosis of PE requires an accurate evaluation which will be made in this investigation by a composite of diagnostic tests including pulmonary angiography, ventilation/perfusion lung scans, venous compression ultrasound, and outcome analysis. The strengths of this proposal are: 1) the importance of the problem of PE in terms of lives lost from underdiagnosis and major bleeding from overdiagnosis; 2) the potential applicability of a new technology for the diagnosis of PE that will have widespread availability; 3) the protocol parallels standard diagnostic strategy without subjecting the patients to risk entirely for the acquisition of data and 4) the team of investigators is strong and has collaborated previously in successful research in PE.

这是一项多中心合作研究，旨在确定对比增强螺旋计算机断层扫描（螺旋CT）诊断急性肺栓塞（PE）的敏感性、特异性、阳性和阴性预测价值。肺栓塞是常见的，但往往未确诊和致命的。螺旋CT是一种几乎无创的检查，通过显示肺动脉血栓的轮廓，为PE的明确诊断提供了可能性。然而，其在PE诊断中的应用尚不清楚。尽管螺旋CT还没有得到充分的验证，但许多医院的医生现在都把它作为一种明确的、唯一的诊断测试。这可能导致过度治疗或治疗不足，这两种情况都有严重的潜在并发症。螺旋CT在PE诊断中的作用需要准确的评估，这将在本研究中通过包括肺血管造影、肺通气/灌注扫描、静脉压迫超声和结果分析在内的综合诊断测试来进行。该建议的优势在于：1)就诊断不足导致的生命损失和过度诊断导致的大出血而言，PE问题的重要性；2) PE诊断新技术的潜在适用性，该技术将得到广泛应用；3)该方案与标准诊断策略相似，而不会使患者完全承担获取数据的风险；4)研究团队强大，以前在PE研究中有过成功的合作。