PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II

肺栓塞 DX-II 的前瞻性研究

• 批准号: 6659858
• 负责人: Pamela K Woodard
• 金额: $ 1.54万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6659858
• 关键词: angiography; bioimaging /biomedical imaging; clinical research; clinical trials; computed axial tomography; cooperative study; diagnosis design /evaluation; human subject; lung imaging /visualization /scanning; noninvasive diagnosis; pulmonary circulation obstruction; ultrasonography; venous thrombosis

(Adapted from the applicant's abstract) This is a multicenter collaborative study to determine the sensitivity, specificity, positive and negative predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal. Spiral CT is a nearly noninvasive test that offers the possibility of a definitive diagnosis of PE by showing the outline of the thrombus in a pulmonary artery. However, its utility in the diagnosis of PE is unknown. Even though spiral CT has not been adequately validated, physicians at many hospitals now use it as a definitive and only diagnostic test. This could lead to overtreatment or undertreatment, both of which have serious potential complications. The role of spiral CT in the diagnosis of PE requires an accurate evaluation which will be made in this investigation by a composite of diagnostic tests including pulmonary angiography, ventilation/perfusion lung scans, venous compression ultrasound, and outcome analysis. The strengths of this proposal are: 1) the importance of the problem of PE in terms of lives lost from underdiagnosis and major bleeding from overdiagnosis; 2) the potential applicability of a new technology for the diagnosis of PE that will have widespread availability; 3) the protocol parallels standard diagnostic strategy without subjecting the patients to risk entirely for the acquisition of data and 4) the team of investigators is strong and has collaborated previously in successful research in PE.

（改编自申请人摘要）这是一项多中心协作研究，旨在确定对比增强螺旋计算机断层扫描（螺旋CT）诊断急性肺栓塞（PE）的敏感性、特异性、阳性和阴性预测值。 肺栓塞是常见的，但往往无法诊断和致命的。 螺旋CT是一种几乎无创的检查，通过显示肺动脉血栓的轮廓，可以明确诊断PE。 然而，其在PE诊断中的效用尚不清楚。 尽管螺旋CT尚未得到充分验证，但许多医院的医生现在将其用作确定且唯一的诊断测试。 这可能导致过度治疗或治疗不足，两者都有严重的潜在并发症。 螺旋CT在PE诊断中的作用需要准确的评估，在本研究中将通过诊断测试的复合物进行评估，包括肺血管造影、通气/灌注肺扫描、静脉压迫超声和结果分析。 这一建议的优点是：1）PE问题的重要性，因为诊断不足和过度诊断导致的大出血造成了生命损失; 2）一种新的PE诊断技术的潜在适用性，将广泛使用; 3）该方案与标准诊断策略并行，而不会使患者完全因数据采集而遭受风险，以及4）研究团队实力雄厚，曾成功合作进行体育研究。