EFFICACY OF PSYCHOSOCIAL THERAPIES FOR DRUG ABUSE

此K02申请的主要目的是促进申请人的 提高患者心理社会治疗效果的职业生涯 物质使用障碍，包括三个辅助目标：(1) 重视“预后不良”药物使用的心理社会治疗 精神障碍(SUD)人群(例如，患有 创伤后应激障碍或双相情感障碍，缺乏动力 治疗，或艾滋病毒；贫穷和/或无家可归；以及市中心妇女)；(2) 运用心理社会手段提高医疗服务质量 临床医生；及。(3)制订新的评估措施，以协助 以上目标，用于研究和临床使用。K02奖将是 有助于加强申请人在以下八个方面的参与 研究，其中六项由NIDA资助：(1)群体认知-行为 双重诊断妇女的治疗(和艾滋病毒补充剂)，一项对照研究 比较一组新的认知行为人群的随机试验 申请人为女性创伤后患者开发的心理疗法 应激障碍(PTSD)和SUD与“照常治疗”对照； 补助金的补充资金侧重于减少老年人感染艾滋病毒的危险行为 样本；(2)双相物质滥用者复吸预防小组 为患者开发和试行综合团体治疗手册 伴双相情感障碍和自闭症；(3)协同治疗可卡因 这项研究是一项多点随机对照试验，比较了 可卡因依赖门诊患者的心理社会治疗；(4)创伤后应激障碍 可卡因依赖妇女的治疗结果：一项随机对照研究 研究人员开发的新认知-行为心理疗法的比较试验 申请者与市内可卡因标准复吸预防- 患有创伤后应激障碍的依赖妇女；(5)ASAM药物标准的有效性 滥用治疗，以测试一种广泛使用的治疗的有效性- 匹配方案及其对公共资助人口的适用性； (6)研究诊断项目，分析两者之间的关系 375例成人就诊患者的创伤后应激障碍和躯体功能障碍；(7)行为 酒精中毒的药物治疗，多部位受控 比较两种心理学和两种药理学的随机试验 对720名酒依赖门诊患者的干预；(8)创伤后应激障碍和 贫穷和无家可归妇女中的药物滥用(史密斯-理查森 基金会)，一项对照随机试验，比较了新的认知- 申请人发展的行为心理疗法与“治疗-- 为患有创伤后应激障碍和/或无家可归的贫困和/或无家可归的妇女颁发的 还将增强申请者扩展到相关领域的潜力 研究领域，并指导新的研究人员。

The primary aim of this K02 application is to further the applicant's career in improving the efficacy of psychosocial treatments for patients with substance use disorder, comprising three subsidiary aims: (1) an emphasis on psychosocial treatments for "poor prognosis" substance use disorder (SUD) populations (e.g., patients who have co-occurring posttraumatic stress disorder or bipolar disorder, low motivation for treatment, or HIV; are poor and/or homeless; and inner-city women); (2) improving the quality of treatment of treatment delivery by psychosocial clinicians; and (3) developing new assessment measures to assist the above goals, for both research and clinical use. The K02 award would be useful to strengthen the applicant's involvement in the following eight studies, six of which are NIDA-funded: (1) Group Cognitive-Behavioral Therapy for Dual Diagnosis Women (and HIV supplement), a controlled randomized trial comparing a new cognitive-behavioral group psychotherapy developed by the applicant for women with posttraumatic stress disorder (PTSD) and SUD versus a "treatment-as-usual" control; a supplement to the grant focuses on reducing HIV risk behaviors in the sample; (2) A Relapse Prevention Group for Bipolar Substance Abusers to develop and pilot-test an integrated group therapy manual for patients with bipolar disorder and SUD; (3) Collaborative Cocaine Treatment Study, a multi-site randomized controlled trial comparing four psychosocial treatments for cocaine-dependent outpatients; (4) PTSD treatment outcomes for cocaine dependent women, a controlled randomized trial comparing the new cognitive-behavioral psychotherapy developed by the applicant versus standard relapse prevention for inner-city cocaine- dependent women with PTSD; (5) Validity of the ASAM Criteria for Drug Abuse Treatment, to test the validity of a widely used treatment- matching protocol and its applicability to a publicly funded population; (6) Research Diagnostic Project, to analyze the relationship between PTSD and SUD among 375 adult treatment-seeking patients; (7) Behavioral and Pharmacologic Treatment of Alcoholism, a multi-site controlled randomized trial comparing two psychosocial and two pharmacologic interventions for 720 outpatients with alcohol dependence; (8) PTSD and substance abuse among poor and homeless women (Smith-Richardson Foundation), a controlled randomized trial comparing the new cognitive- behavioral psychotherapy developed by the applicant versus "treatment- as-usual" for poor and/or homeless women with PTSD and SUD. The award would also enhance the applicant's potential to expand into related areas of research and to mentor new researchers.