Epilepsy and stress: an explanatory electrophysiological model

癫痫和压力：解释性电生理学模型

• 批准号: nhmrc : 1040028
• 负责人: Dr Patrick O'Brien
• 金额: $ 6.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epilepsy-stress-an-electrophysiological-model/111319
• 关键词: Epilepsy; stress; explanatory; electrophysiological; model

Epilepsy is one of the most common recurrent neurological disorders worldwide, affecting between 1 and 2% of the population. The cascade of events culminating in epilepsy, or the role of seizures in altering brain structures and circuits has been difficult to define. Previous work from our group has shown that stress markedly accelerates the process of epilepsy development. I am developing a model of brain functioning from observed brain cells to chart the changes associated with seizures, stress, and potential treatments.

癫痫是世界范围内最常见的复发性神经系统疾病之一，影响1%至2%的人口。导致癫痫的一连串事件，或者癫痫发作在改变大脑结构和回路中的作用一直难以定义。我们小组以前的工作表明，压力显着加速癫痫发展的过程。我正在开发一个大脑功能模型，从观察到的脑细胞中绘制与癫痫发作，压力和潜在治疗相关的变化。