Pediatric Physician Scientists in Molecular Biology

描述（由申请人提供）：为了增加从基础科学研究到临床应用的知识转移，这将改善儿童的健康，我们建议在儿科系内维持一个儿童健康研究中心。 CHRCDA的主要重点将是在儿童疾病的分子生物学方面培训年轻的儿科医生，重点是将他们的实验发现转化为改善儿童保健。 CHRCDA将专注于生物医学研究的四个领域：（1）遗传学和发育生物学，（2）与肺损伤相关的肺部疾病，（3）造血系统疾病，以及（4）感染性疾病，包括使用微生物作为基因传递载体。 我们已经成功地利用以前的CHRCDA提供的资源培训了独立的儿科研究人员，并提供了一组经验丰富的CRHC导师和来自UAB和儿科部门的机构支持。 在这个应用程序中，我们将建立在我们以前的经验，并修改我们的培训计划，包括当代临床研究的深入研究，以及采用基因组和蛋白质组技术和生物信息学系统的实验方法的正式介绍。 我们的目标是以研究技术和方法为基础，加强指导研究经验。 我们相信，这项培训计划将产生最具竞争力的年轻研究人员，并促进独立研究事业的发展。

DESCRIPTION (provided by applicant): In order to increase the transfer of knowledge from basic science studies into clinical applications that will improve the health of children, we propose to maintain a Child Hearth Research Center within the Department of Pediatrics. The major focus of the CHRCDA will be to train young pediatricians in the molecular biology of diseases of childhood with an emphasis on translating their experimental findings into improved healthcare for children. The CHRCDA will focus on four areas of biomedical research: (1) genetics and developmental biology, (2) pulmonary diseases associated with lung injury, (3) diseases of the hematopoietic system, and (4) infectious diseases, including the use of microbes as vectors of gene delivery. We have successfully trained independent pediatric investigators utilizing the resources provided by the previous CHRCDA and offer an outstanding group of experienced CRHC mentors and the institutional support from UAB and the Department of Pediatrics. In this application, we will build on our previous experience and modify our training program to include intensive studies in contemporary clinical research as well as formal introductions to experimental approaches employing genomic and proteomic technologies and bioinformatic systems. Our goal is to enhance the mentored research experience with a foundation of research techniques and approaches. We believe that this training program will produce the most competitive young investigators and foster the development of independent research careers.