FMRI AND TMS ANALYSIS OF CEREBELLAR COGNITIVE FUNCTION
小脑认知功能的 FMRI 和 TMS 分析
基本信息
- 批准号:6639129
- 负责人:
- 金额:$ 27.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-07-01 至 2005-06-30
- 项目状态:已结题
- 来源:
- 关键词:behavioral /social science research tag bioimaging /biomedical imaging brain imaging /visualization /scanning central neural pathway /tract cerebellum clinical research functional magnetic resonance imaging human subject neocortex neuropsychological tests short term memory transcranial magnetic stimulation
项目摘要
DESCRIPTION: (Adapted from the Investigator's Abstract)
The goal of this research is to elucidate the role of the cerebellum in
cognitive function by combining sophisticated event-related functional magnetic
resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) techniques
with tasks of human verbal working memory. Using the Sternberg paradigm as the
test of verbal working memory, we hypothesize that regions of the cerebellum
can be differentially activated by sensory acquisition, motor control-error
correction, and executive search processes. We further hypothesize that by
increasing cognitive demands separately during these encoding, maintenance and
retrieval phases, corresponding process-specific increases in the same regional
cerebellar activation will occur. We will further test for which of the
fMRI-identified regions of activation are necessary for performance using TMS,
a technique for producing a transient functional disruption of neural
circuitry. We will develop methods and software for integration fMRI and TMS,
use TMS to disrupt cerebellar, neocortical and both cerebellar and neocortical
areas known to activate during working memory, and cerebellar regions shown to
activate during verbal working memory as a determined by our fMRI studies.
These data will lead to two studies of cerebro-cerebellar interactions in
cognition, in which we hypothesize that: (1) frontal-cerebellar and
temporal/parietal-cerebellar circuits are linked with the articulatory control
and phonological store components of working memory, and (2) search and
selection are dissociable in explicit, semantic, and working memory retrieval.
Upon completion of this project, the processes that influence cerebella
activation for higher cognitive function, the importance of these activations
for task performance, and the specific interactions of cortical and cerebellar
function for cognitive performance will be defined with greater psychological
specification and localization than ever before.
描述:(改编自研究者摘要)
这项研究的目的是阐明小脑在
结合复杂的事件相关功能磁
磁共振成像(fMRI)和经颅磁刺激(TMS)技术
人类语言工作记忆的任务。使用斯滕贝格范式作为
在语言工作记忆的测试中,我们假设小脑的区域
可以通过感觉获取、运动控制错误
纠正和执行搜索过程。我们进一步假设,
在这些编码、维护和
检索阶段,相应的过程特定的增加,在同一区域
小脑会激活我们将进一步测试
fMRI鉴定的激活区域对于使用TMS的性能是必要的,
一种用于产生神经系统的瞬时功能中断的技术,
电路我们将开发整合fMRI和TMS的方法和软件,
使用TMS破坏小脑、新皮质以及小脑和新皮质
已知在工作记忆中激活的区域,以及小脑区域,
在我们的功能磁共振成像研究中确定的言语工作记忆中激活。
这些数据将导致两项关于小脑-小脑相互作用的研究,
认知,其中我们假设:(1)额小脑和
颞/顶叶-小脑回路与发音控制有关
工作记忆的语音储存成分,以及(2)搜索和
选择在外显记忆、语义记忆和工作记忆提取中是分离的。
在这个项目完成后,影响小脑的过程
激活高级认知功能,这些激活的重要性
以及大脑皮层和小脑之间的特定相互作用
认知性能的功能将被定义为具有更大的心理
比以往任何时候都更规范和本地化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN E DESMOND其他文献
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{{ truncateString('JOHN E DESMOND', 18)}}的其他基金
Investigation of cerebellar involvement in cognitive sequencing
小脑参与认知测序的研究
- 批准号:
10684332 - 财政年份:2022
- 资助金额:
$ 27.37万 - 项目类别:
Investigation of Cerebellar Involvement in Cognitive Function
小脑参与认知功能的研究
- 批准号:
9225061 - 财政年份:2015
- 资助金额:
$ 27.37万 - 项目类别:
Investigation of Cerebellar Involvement in Cognitive Function
小脑参与认知功能的研究
- 批准号:
9420634 - 财政年份:2015
- 资助金额:
$ 27.37万 - 项目类别:
fMRI Investigations of Cognition in Alcoholics
酗酒者认知功能磁共振成像研究
- 批准号:
8525260 - 财政年份:2010
- 资助金额:
$ 27.37万 - 项目类别:
fMRI Investigations of Cognition in Alcoholics
酗酒者认知功能磁共振成像研究
- 批准号:
8135197 - 财政年份:2010
- 资助金额:
$ 27.37万 - 项目类别:
fMRI Investigations of Cognition in Alcoholics
酗酒者认知功能磁共振成像研究
- 批准号:
8316430 - 财政年份:2010
- 资助金额:
$ 27.37万 - 项目类别:
fMRI Investigations of Cognition in Alcoholics
酗酒者认知功能磁共振成像研究
- 批准号:
8706664 - 财政年份:2010
- 资助金额:
$ 27.37万 - 项目类别:
fMRI Investigations of Cognition in Alcoholics
酗酒者认知功能磁共振成像研究
- 批准号:
7985384 - 财政年份:2010
- 资助金额:
$ 27.37万 - 项目类别: