FMRI AND TMS ANALYSIS OF CEREBELLAR COGNITIVE FUNCTION

描述：(改编自《调查者摘要》) 本研究的目的是阐明小脑在脑内的作用。 结合复杂的事件相关功能磁学实现的认知功能 磁共振成像(FMRI)和经颅磁刺激(TMS)技术 人类言语工作记忆的任务。使用Sternberg范式作为 言语工作记忆测试，我们假设小脑的区域 可通过感觉获得、运动控制错误而不同地激活 更正和高管招聘流程。我们进一步假设，通过 在这些编码、维护和维护过程中分别增加认知需求 检索阶段，在同一区域内相应的流程特定增加 小脑就会被激活。我们将进一步测试哪些是 FMRI识别的激活区域对于使用TMS的操作是必需的， 一种产生一过性神经功能紊乱的技术 电路。我们将开发集成fMRI和TMS的方法和软件， 使用TMS干扰小脑、新皮质以及小脑和新皮质 已知在工作记忆中激活的区域，以及显示为 在言语工作记忆中激活，正如我们的功能磁共振研究所确定的那样。 这些数据将导致两项关于大脑-小脑相互作用的研究 认知，其中我们假设：(1)额-小脑和 颞叶/顶叶-小脑环路与关节控制有关 和工作记忆的语音存储成分，以及(2)搜索和 在外显、语义和工作记忆提取中，选择是可分离的。 在这个项目完成后，影响小脑的过程 更高认知功能的激活，这些激活的重要性 对于任务绩效，以及大脑皮层和小脑的特定交互作用 认知表现的功能将被定义为更大的心理 比以往任何时候都更加规范和本地化。

DESCRIPTION: (Adapted from the Investigator's Abstract) The goal of this research is to elucidate the role of the cerebellum in cognitive function by combining sophisticated event-related functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) techniques with tasks of human verbal working memory. Using the Sternberg paradigm as the test of verbal working memory, we hypothesize that regions of the cerebellum can be differentially activated by sensory acquisition, motor control-error correction, and executive search processes. We further hypothesize that by increasing cognitive demands separately during these encoding, maintenance and retrieval phases, corresponding process-specific increases in the same regional cerebellar activation will occur. We will further test for which of the fMRI-identified regions of activation are necessary for performance using TMS, a technique for producing a transient functional disruption of neural circuitry. We will develop methods and software for integration fMRI and TMS, use TMS to disrupt cerebellar, neocortical and both cerebellar and neocortical areas known to activate during working memory, and cerebellar regions shown to activate during verbal working memory as a determined by our fMRI studies. These data will lead to two studies of cerebro-cerebellar interactions in cognition, in which we hypothesize that: (1) frontal-cerebellar and temporal/parietal-cerebellar circuits are linked with the articulatory control and phonological store components of working memory, and (2) search and selection are dissociable in explicit, semantic, and working memory retrieval. Upon completion of this project, the processes that influence cerebella activation for higher cognitive function, the importance of these activations for task performance, and the specific interactions of cortical and cerebellar function for cognitive performance will be defined with greater psychological specification and localization than ever before.