fMRI and TMS Analysis of Cerebellar Cognitive Function

小脑认知功能的 fMRI 和 TMS 分析

• 批准号: 6984642
• 负责人: JOHN E DESMOND
• 金额: $ 24.73万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6984642
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; central neural pathway /tract; cerebellum; clinical research; executive function; functional magnetic resonance imaging; human subject; neocortex; neural information processing; neuropsychological tests; neuropsychology; short term memory; transcranial magnetic stimulation; young adult human (21-34)

DESCRIPTION (provided by applicant): The overall goal of this research is to better understand the contribution of the cerebellum and cerebrocerebellar networks to cognitive function by combining functional MRI (fMRI) and transcranial magnetic stimulation (TMS) techniques with tasks of verbal working memory. The Sternberg verbal working memory task, with three temporally distinct phases of encoding, maintenance, and retrieval, is an ideal model system for studying cerebro-cerebellar contributions to cognition. Our studies to date have supported a cerebrocerebellar verbal working memory model that emphasizes a functional link between neocortical articulatory control regions, such as Broca's Area, to the superior cerebellum, and a second network that links neocortical substrates of phonological storage, located in inferior parietal regions, to the inferior cerebellum. We propose to further test and extend this model in three specific aims. The first will emphasize the encoding phase and will test the hypothesis that the superior cerebellum and posterior frontal regions participate in the initial preparation of the articulatory trajectory independent of stimulus modality. The second aim will emphasize the maintenance phase. We will test the hypothesis that the right inferior cerebellum is functionally linked to the left inferior parietal region and that activation in these regions will be modulated in tandem when phonological storage demands are systematically manipulated. In addition, we will test the hypothesis that a transient phonological storage deficit syndrome, similar to that observed in left temporal-parietal lesioned patients, can be reproduced in the TMS lab using stimulation to left inferior parietal and right inferior cerebellar regions. The third aim will emphasize the retrieval phase. The retrieval phase of the Sternberg task, which requires utilization of the stored information, has elicited the least amount of cerebellar activation in our event-related investigations. We hypothesize that by increasing the executive demands of the task - by imposing additional processing requirements - we will observe increases in retrieval-phase-related cerebellar activation. We further hypothesize that the amount of behavioral disruption produced by TMS in the retrieval phase will be correlated with the amount of retrieval-phase related cerebellar activation.

描述（由申请人提供）：本研究的总体目标是通过将功能性MRI（fMRI）和经颅磁刺激（TMS）技术与言语工作记忆任务相结合，更好地了解小脑和小脑前叶网络对认知功能的贡献。斯滕贝格言语工作记忆任务具有编码、维持和提取三个时间上不同的阶段，是研究小脑-小脑对认知的贡献的理想模型系统。迄今为止，我们的研究已经支持了小脑的言语工作记忆模型，该模型强调了新皮质发音控制区域（如布罗卡区）与上级小脑之间的功能联系，以及第二个网络，该网络将位于顶叶下部区域的语音存储的新皮质基底与小脑下部联系起来。我们建议在三个具体目标中进一步测试和扩展该模型。第一个将强调编码阶段，并将测试的假设，即上级小脑和后额叶区域参与的初始准备的发音轨迹独立的刺激方式。第二个目标将强调维持阶段。我们将测试的假设，即右下小脑功能上连接到左下顶叶区域，这些区域的激活将调制串联时，语音存储的需求进行系统的操作。此外，我们将测试的假设，一个短暂的语音存储缺陷综合征，类似于左颞顶叶病变患者中观察到的，可以在TMS实验室使用刺激左下顶叶和右下小脑区域再现。第三个目标将强调检索阶段。斯滕贝格任务的提取阶段需要利用存储的信息，在我们的事件相关研究中，提取阶段引起的小脑激活最少。我们假设，通过增加任务的执行要求-通过施加额外的处理要求-我们将观察到检索相相关的小脑激活的增加。我们进一步假设，在检索阶段由TMS产生的行为中断的量将与检索阶段相关的小脑激活的量相关。