Threading receptors for cellulose and chitin

纤维素和甲壳质的螺纹受体

• 批准号: 2132604
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2132604
• 关键词: Threading; receptors; cellulose; chitin

Polysaccharides are the dominant organic molecules in the biosphere, and thus key renewable resources. However the most abundant, including cellulose and chitin, are generally the most difficult to utilise due to extreme insolubility. At present there is no method for mobilising these materials in water under mild conditions, so that modifications involve chemical transformations in aggressive media or the slow action of enzymes on undissolved solids. Dissolution in aqueous media at biological pH would allow new paths to exploitation, especially the rapid transformation or degradation by engineered enzymes. The project will investigate a new approach to this problem, employing receptors which can thread onto the polysaccharide and effectively carry it into solution. The work will involve the design and synthesis of receptors, studies of their interaction with oligo/polysaccharides, and investigations of the reactivity of any complexes which can be shown to form.

多糖是生物圈中占主导地位的有机分子，因此是关键的可再生资源。然而，最丰富的，包括纤维素和几丁质，通常是最难以利用的，由于极端的不溶性。目前还没有在温和条件下在水中动员这些材料的方法，因此修饰涉及在侵蚀性介质中的化学转化或酶对不溶解固体的缓慢作用。在生物pH的水介质中溶解将允许新的开发途径，特别是通过工程酶的快速转化或降解。该项目将研究解决这个问题的新方法，采用可以连接到多糖上并有效将其带入溶液的受体。这项工作将涉及受体的设计和合成，研究它们与寡糖/多糖的相互作用，以及研究可以形成的任何复合物的反应性。