Contaminant-FreeKetene Synthesis for Asymmetric Catalysi

用于不对称催化的无污染乙烯酮合成

• 批准号: 6620589
• 负责人: THOMAS C. LECTKA
• 金额: $ 22.22万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6620589
• 关键词: catalyst; chemical standardization; chemical synthesis; drug design /synthesis /production; enolate; halogenation; ketene; lactams; stereochemistry

DESCRIPTION: (provided by applicant) A Specific Aims. The main objectives of this proposal are 1) to develop an efficient, inexpensive method for the generation of contaminant free, reactive ketenes, and 2) to apply this new methodology to a number of diverse catalytic asymmetric transformations that represent important problems in synthetic organic chemistry, including the catalytic, asymmetric synthesis of Beta-lactams; catalytic, asymmetric halogenation reactions; polycomponent or tandem catalytic reactions; and asymmetric catalysis on columns. Most of our proposed methodology depends on the putative intermediacy of enolates derived from the reaction of ketenes and catalytic nucleophiles. All the optically enriched, chiral products of our reactions are meant to be either pharmacologically active, or potentially so, or to represent key intermediates and branch points in the synthesis of medicinally or academically interesting target molecules.

描述：（由申请人提供）具体目标。本提案的主要目标是：1)开发一种高效、廉价的方法