Contaminant-FreeKetene Synthesis for Asymmetric Catalysi

描述：(申请人提供)一个明确的目标。这项提议的主要目标是：1)开发一种高效、廉价的方法，用于 产生无污染的反应性烯烃，以及2)应用这一新技术 一系列不同的催化不对称转化的方法学 代表合成有机化学中的重要问题，包括 不对称催化合成β-内酰胺 卤化反应；多组分或串联催化反应；以及 柱上的不对称催化作用。我们提出的大多数方法都依赖于 烯烃与烯烃反应所产生的烯醇酸盐的假定中间体 催化亲核试剂。我们所有的光学富集型手性产品 反应要么是药理上的，要么是潜在的， 或代表合成过程中的关键中间体和分支点 医学上或学术上感兴趣的目标分子。

DESCRIPTION: (provided by applicant) A Specific Aims. The main objectives of this proposal are 1) to develop an efficient, inexpensive method for the generation of contaminant free, reactive ketenes, and 2) to apply this new methodology to a number of diverse catalytic asymmetric transformations that represent important problems in synthetic organic chemistry, including the catalytic, asymmetric synthesis of Beta-lactams; catalytic, asymmetric halogenation reactions; polycomponent or tandem catalytic reactions; and asymmetric catalysis on columns. Most of our proposed methodology depends on the putative intermediacy of enolates derived from the reaction of ketenes and catalytic nucleophiles. All the optically enriched, chiral products of our reactions are meant to be either pharmacologically active, or potentially so, or to represent key intermediates and branch points in the synthesis of medicinally or academically interesting target molecules.