The Influences of Polyphenol Consumption on Cognitive Performance and Neuroimaging Phenotypes of Cognitive Decline

预期寿命的延长以及与年龄相关的阿尔茨海默病（AD）和其他痴呆症形式的认知能力下降的日益普遍，对公众健康构成了重大威胁。很大一部分痴呆症病例被认为可以通过改变包括饮食在内的生活方式因素来预防。许多神经成像生物标志物与衰老、前驱或发展中的痴呆期间的认知表现以及从轻度认知障碍（MCI）转变为AD的可能性相关，包括内侧颞叶结构的体积或其他变化。较高的饮食质量通常部分表现为摄入更多富含多酚的食物，包括水果和蔬菜。在纵向研究中，饮食质量与MRI测量包括海马体积有关，而干预研究中，处方有效的多酚源可以改善轻度认知障碍患者的学习和回忆能力。我们使用的数据收集包括饮食、认知、神经成像和代谢组学数据，包括英国生物银行和Airwave队列。目前正在为参与者生成多酚消耗概况，这将用于确定其对认知测试分数和mri衍生表型的影响。利用这些信息，我们希望对多酚摄入、认知表现和与年龄相关的认知衰退相关的MRI表型之间的关系获得新的见解。

Increasing life expectancy and the rising prevalence of age-associated cognitive decline in the form of Alzheimer's disease (AD) and other dementias pose a major threat to public health. A significant portion of dementia cases are considered preventable through the modification of lifestyle factors including diet. Numerous neuroimaging biomarkers are associated with cognitive performance during ageing, prodromal or developed dementia and the likelihood of conversion from mild cognitive impairment (MCI) to AD, including volumetric or other changes in structures of the medial temporal lobe. Higher diet quality is typically partially characterised by higher intake of polyphenol-rich foods including fruits and vegetables. Diet quality is associated with MRI measures including hippocampal volume in longitudinal studies, while intervention studies prescribing potent polyphenol sources have improved measures of learning and recall ability in MCI individuals. We are using data collections comprising dietary, cognitive, neuroimaging and metabolomic data including the UK Biobank and Airwave cohorts. Polyphenol consumption profiles are currently being generated for participants, which will be used to determine its influence on cognitive test scores and MRI-derived phenotypes. Using this information, we hope to gain new insight into relationships between polyphenol intake, cognitive performance and MRI phenotypes implicated in age-associated cognitive decline.