IMPACT OF CHRONIC GDNF ON RECOVERY FROM 6-OHDA

慢性 GDNF 对 6-OHDA 恢复的影响

• 批准号: 6639604
• 负责人: Martha D Bohn
• 金额: $ 50.42万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6639604
• 关键词: 6 hydroxydopamine; Parkinson's disease; age difference; corpus striatum; disease /disorder model; dopamine; experimental brain lesion; glia; laboratory rat; microdialysis; neural degeneration; neurochemistry; neuroprotectants; neurotoxins; neurotrophic factors; polymerase chain reaction; single cell analysis; substantia nigra; transfection /expression vector

项目成果

Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity?

• DOI: 10.1016/s1353-8020(02)00019-6
• 发表时间: 2002-09
• 期刊: Parkinsonism & related disorders
• 影响因子: 4.1
• 作者: M. Zigmond;T. Hastings;R. Perez

Quantitative analyses of GFRalpha-1 and GFRalpha-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat.

对黑质纹状体系统中 GFRα-1 和 GFRα-2 mRNA 以及酪氨酸羟化酶蛋白的定量分析揭示了大鼠单侧 6-OHDA 损伤后的双侧代偿性变化。

• DOI: 10.1016/j.brainres.2004.05.003
• 发表时间: 2004
• 期刊: Brain research.
• 作者: Kozlowski,DA;Miljan,EA;Bremer,EG;Harrod,CG;Gerin,C;Connor,B;George,D;Larson,B;Bohn,MC
• 通讯作者: Bohn,MC

Effect of 6-hydroxydopamine on striatal GDNF and nigral GFRalpha1 and RET mRNAs in the adult rat.

• DOI: 10.1016/s0169-328x(03)00289-4
• 发表时间: 2003-10
• 期刊: Brain research. Molecular brain research
• 作者: Amanda D. Smith;M. Antion;M. Zigmond;M. Austin

Behavioral improvement and dopamine release in a Parkinsonian rat model.

帕金森病大鼠模型的行为改善和多巴胺释放。

• DOI: 10.1016/s0304-3940(02)00672-9
• 发表时间: 2002
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Gerin,Christine