Community Based Clinical Trials Education Program

加州大学圣地亚哥分校癌症中心是加州大学圣地亚哥分校的一个有组织的研究单位。它由120多名成员组成，他们在15个大学部门担任学术职务，另有几名成员来自整个地区的其他学术和研究机构。它的使命是减少癌症的发病率、发病率和死亡率。自1979年4月1日以来，癌症中心作为NCI指定的癌症中心一直得到资助，致力于优秀的基础、翻译、行为和临床研究。全国范围内的低临床试验应收率被认为是在癌症的预防、诊断和治疗方面取得所需快速进展的主要障碍。对女性和少数群体成员的代表性样本进行临床试验更加困难，限制了这些研究结果的广泛适用性。在过去的五年中，加州大学圣地亚哥分校癌症中心开发并试点了一个区域范围内的基础设施的各个组成部分，旨在减少肿瘤学家对临床试验转介的障碍，并教育社区肿瘤学家有关开放临床试验的知识。已经测试了旨在促进临床试验收益的八个计划组成部分和许多子组成部分。它们包括：1)临床试验晚宴系列会议；2)地区癌症中心领导人联盟；3)临床试验网站网络；4)随机试验，以评估传播临床试验信息的方法；5)“可及”数据库；6)以研究为导向的社区推广计划；7)媒体伙伴关系；8)立法宣传推力。该提案将继续测试、开发、补充和报告这些不同的计划组成部分在促进临床试验应计费用方面的有效性。对在标准基础设施内评估干预措施影响的多种方法进行了测试，发现这些方法无效。临床试验。基础设施进行了广泛的修订，以便在未来的工作中进行准确的终端评估。

The UCSD Cancer Center is an Organized Research Unit of the University of California, San Diego. It is comprised of over 120 members with academic appointments in 15 university departments, plus several members from other academic and research institutions throughout the region. Its mission is to reduce the incidence of, and morbidity and mortality from, cancer. The Cancer Center has had continuous funding as an NCI designated cancer center since April 1, 1979 and is oriented toward excellent basic, translational, behavioral, and clinical research. The low clinical trials accrual rates nationwide are recognized as a major barrier to achieving the rapid progress desired in the prevention, diagnosis, and treatment of cancer. The accrual of a representative sample of women and members of minority groups to clinical trials has been even more difficult to accomplish, limiting the broad applicability of these research findings. Over the past five years, UCSD Cancer Center has developed and pilotlested various components of a region wide infrastructure designed to reduce oncologists' barriers to clinical trials referral and to educate community oncologists about open clinical trials. Eight program components and numerous sub-components aimed at promoting clinical trials accrual have been tested. They include: 1) The Clinical Trials Dinner Meeting Series; 2) the Consortium of Regional Cancer Center Leaders; 3) a network of clinical trials web sites; 4) a randomized trial to evaluate methods to disseminate clinical trials information; 5) an "in- reach" data base; 6) research-driven community outreach programs; 7) a media partnership; and 8) a legislative advocacy thrust. This proposal will continue to test, develop, supplement, and report upon the effectiveness of these various program components in promoting accrual to clinical trials. Multiple approaches to assess the impact of the interventions within standard infrastructure were tested and found to be ineffective. The clinical trials. infrastructure has had extensive revisions to allow for accurate endpoint assessment with future efforts.