Synthesis of alkenes by conformationally directed transition metal-free couplings to sp2 carbon

通过构象定向无过渡金属与 sp2 碳偶联合成烯烃

• 批准号: 2183154
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2183154
• 关键词: Synthesis; alkenes; conformationally; directed; transition

The synthesis of alkenes (key components of drugs, natural products, fragrances and monomers for materials synthesis) was revolutionised by the discovery of transition-metal promoted couplings. However, transition metals are generally expensive and suffer from supply chain volatility, so alternative direct routes to alkenes are of value. In this project we will explore the use of conformationally directed substitutions at sp2 hybridised carbons as an alternative, practically simple and sustainable approach to the synthesis of alkenes. We aim to develop synthetic methods that avoid the use of halogens and transition metals, and which exploit mechanistically unusual reactivity inherent in conformationally restricted functions such as amides and ureas. The outcome of the project will have an impact on the EPSRC research area of physical sciences.

烯烃（药物、天然产物、香料和材料合成单体的关键组分）的合成因过渡金属促进的偶联的发现而发生革命性变化。然而，过渡金属通常价格昂贵，并且受到供应链波动的影响，因此替代烯烃的直接路线是有价值的。在这个项目中，我们将探索使用构象定向取代sp2杂化碳作为一种替代，实际上简单和可持续的方法来合成烯烃。我们的目标是开发合成方法，避免使用卤素和过渡金属，并利用机械不寻常的反应性固有的构象限制功能，如酰胺和脲。该项目的成果将对EPSRC的物理科学研究领域产生影响。