Outside to inside: The relationship of eukaryotic homologues of serine-threonine kinase signalling in bacterial pathogens to antibiotic resistance.

从外到内：细菌病原体中丝氨酸-苏氨酸激酶信号传导的真核同源物与抗生素耐药性的关系。

• 批准号: 2203471
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2203471
• 关键词: Outside; inside; relationship; eukaryotic; homologues

Programme overview:This MRC-funded doctoral training partnership (DTP) brings together cutting-edge molecular and analytical sciences with innovative computational approaches in data analysis to enable students to address hypothesis-led biomedical research questions. This is a 4-year programme whose first year involves a series of taught modules and two laboratory-based research projects that lead to an MSc in Interdisciplinary Biomedical Research. The first two terms consist of a selection of taught modules that allow students to gain a solid grounding in multidisciplinary science. Students also attend a series of masterclasses led by academic and industry experts in areas of molecular, cellular and tissue dynamics, microbiology and infection, applied biomedical technologies and artificial intelligence and data science. During the third and summer terms students conduct two eleven-week research projects in labs of their choice. Project:Antimicrobial drug resistance (AMR) is a growing threat to public health worldwide, and is a complex socioeconomic and scientific problem. Despite the clear social need for the development of novel antimicrobials, investment in this sector has declined due to a number of financial and commercial factors and remains far below the level required to keep pace with newly emerging forms of resistance. Therefore, antimicrobial drug development and target discovery is increasingly becoming the role of academia and smaller biotech companies. To control the AMR crisis, new methods, knowledge and trained specialists dedicated to antimicrobial research are required. Our research involves studying Enterococci, a group of bacteria that form part of our normal gut flora yet can cause opportunistic infections following surgery. Enterococci are resistant to two important classes of antibacterial drugs, and our research has shown that there is a protein that links the two types of resistance. When this protein is removed, chemically or genetically, the bacteria are no longer resistant to both antibacterial drug types. With further research, we may be able to discover novel drugs that will knock out this protein, allowing older antibiotics to be once again effective. We also need to explore if this observation can be extended to other bacterial pathogens including Clostridium difficile (C. diff); a species which causes severe disease in elderly and immunosuppressed patients and is a great burden on healthcare systems world-wide.

项目概述：这个mrc资助的博士培训伙伴关系（DTP）将尖端的分子和分析科学与创新的数据分析计算方法结合在一起，使学生能够解决以假设为主导的生物医学研究问题。这是一个为期4年的课程，第一年包括一系列教学模块和两个基于实验室的研究项目，最终获得跨学科生物医学研究硕士学位。前两个学期包括一系列教学模块，让学生在多学科科学方面打下坚实的基础。学生还将参加一系列由分子、细胞和组织动力学、微生物学和感染、应用生物医学技术、人工智能和数据科学等领域的学术和行业专家主持的大师班。在第三学期和夏季学期，学生在他们选择的实验室进行两个为期11周的研究项目。项目：抗微生物药物耐药性（AMR）是世界范围内日益严重的公共卫生威胁，是一个复杂的社会经济和科学问题。尽管开发新型抗微生物药物有明显的社会需求，但由于一些财政和商业因素，该部门的投资有所下降，仍远低于应对新出现的耐药形式所需的水平。因此，抗菌药物的开发和靶点的发现正日益成为学术界和小型生物技术公司的角色。为了控制抗菌素耐药性危机，需要新的方法、知识和专门从事抗菌素研究的训练有素的专家。我们的研究包括研究肠球菌，这是一组细菌，构成了我们正常肠道菌群的一部分，但可能在手术后引起机会性感染。肠球菌对两种重要的抗菌药物具有耐药性，我们的研究表明，有一种蛋白质将这两种耐药性联系起来。当这种蛋白质从化学上或基因上被去除后，细菌就不再对这两种抗菌药产生抗药性。随着进一步的研究，我们可能会发现新的药物来敲除这种蛋白质，让旧的抗生素再次有效。我们还需要探索这一观察结果是否可以扩展到其他细菌病原体，包括艰难梭菌（C. diff）；在老年人和免疫抑制患者中引起严重疾病的一种，是全世界卫生保健系统的巨大负担。