MOLECULAR EVOLUTION OF P. FALCIPARUM AND P VIVAX

恶性疟原虫和间日疟原虫的分子进化

• 批准号: 7024924
• 负责人: Ananias Alberto Escalante
• 金额: $ 6.22万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7024924
• 关键词: Aves; Plasmodium; Plasmodium falciparum; Primates; Rodentias; animal population genetics; antigens; biochemical evolution; circumsporozoite protein; cytochrome oxidase; ethology; gene expression; genetic polymorphism; genetic recombination; genotype; geographic site; host organism interaction; human data; malaria; malaria vaccines; molecular cloning; nucleic acid sequence; polymerase chain reaction; protein kinase; vaccine development

DESCRIPTION (Adapted from the Applicant's Abstract): This proposal seeks to apply concepts from evolutionary biology to the study of both human and non-human malaria parasites, with the broad goal of gaining analyzing their phylogenetic relationships and of characterizing the amount, origin and manner of maintenance of genetic diversity in various genes encoding human candidate immunogens. Four primary aims are to be pursued, including: (1) to establish phylogenetic relationships relating the various mammalian malaria parasites to each other and to those of other Haemosporina, emphasizing the origins and evolutionary history of P. falciparum and P. vivax; (2) using this phylogenetic tree as a base, to identify factors affecting the evolution of major candidate vaccine immunogens; 3) to compare the extent, origin and maintenance of genetic diversity among candidate immunogens from geographically diverse samples of P. falciparum and of P. vivax; and 4) to correlate intra-host parasite genetic diversity and clinical manifestations of disease in P. falciparum-infected children in western Kenya. Overall, the proposed body of work seeks to establish the origins of the malaria parasites, to provide a basis for developing a multivalent malaria vaccine and to define the distribution of genetic diversity among malaria parasites across a broad geographic area.

描述（根据申请人的摘要改编）：该提案试图 将进化生物学的概念应用于人类和人类的研究 非人类疟疾寄生虫，其广泛的目标是获得分析 系统发育关系以及表征数量，起源和方式 维持编码人类候选者的各种基因的遗传多样性 免疫原子。要追求四个主要目标，包括：（1）建立 系统发育关系将各种哺乳动物疟疾寄生虫与 彼此以及其他嗜血杆菌的人，强调起源 恶性疟原虫和Vivax的进化史； （2）使用这种系统发育 树作为基础，以确定影响主要候选人演变的因素 疫苗免疫原子； 3）比较遗传的程度，起源和维持 候选人免疫的多样性来自P. 恶性疟原虫和Vivax； 4）与宿主内寄生虫遗传相关 恶性疟原虫感染的疾病的多样性和临床表现 肯尼亚西部的孩子。 总体而言，拟议的工作主体旨在建立 疟疾寄生虫，为发展多价疟疾提供基础 疫苗并定义疟疾之间遗传多样性的分布 跨地理区域的寄生虫。

项目成果

A comparative study of the genetic diversity of the 42kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax.

恶性疟原虫和间日疟原虫裂殖子表面蛋白1 42kDa片段遗传多样性的比较研究。

• DOI: 10.1016/j.meegid.2006.08.002
• 发表时间: 2007
• 期刊: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
• 作者: Pacheco,MAndreina;Poe,AmandaC;Collins,WilliamE;Lal,AltafA;Tanabe,Kazuyuki;Kariuki,SimonK;Udhayakumar,Venkatachalam;Escalante,AnaniasA
• 通讯作者: Escalante,AnaniasA

Molecular evolution and intragenic recombination of the merozoite surface protein MSP-3alpha from the malaria parasite Plasmodium vivax in Thailand.

泰国疟原虫间日疟原虫裂殖子表面蛋白 MSP-3α 的分子进化和基因内重组。

• DOI: 10.1017/s0031182005007547
• 发表时间: 2005
• 期刊: Parasitology
• 影响因子: 2.4
• 作者: Mascorro,CN;Zhao,K;Khuntirat,B;Sattabongkot,J;Yan,G;Escalante,AA;Cui,L
• 通讯作者: Cui,L

Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?

• DOI: 10.4269/ajtmh.2008.79.320
• 发表时间: 2008-09-01
• 期刊: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
• 影响因子: 3.3
• 作者: Hamel, Mary J.;Greene, Carolyn;Slutsker, Laurence
• 通讯作者: Slutsker, Laurence