The Development of New Chemical-Tools to Study Chemokines Properties and Functions

研究趋化因子性质和功能的新化学工具的开发

• 批准号: 2211233
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2211233
• 关键词: Development; New; Chemical; Tools; Study

Chemokines are proteins that play a critical role in cell migration (chemotaxis) in a range of human diseases including cancer. This project will focus on the chemical synthesis of specifically modified chemokines (e.g. nitrated, sulfated, fluorinated) with the aim of providing unique chemical-biology tools that can be used to develop a greater understanding of the biology of this important family of proteins. Key to this work will be the development of a novel combinatorial ligation approach which will be used to generate chemokine libraries in a rapid and efficient manner. The work will also look to develop the first CCL2 targeting PROTAC.

趋化因子是在包括癌症在内的一系列人类疾病中在细胞迁移（趋化性）中起关键作用的蛋白质。该项目将专注于特定修饰趋化因子（例如硝化，硫酸化，氟化）的化学合成，目的是提供独特的化学生物学工具，可用于更好地了解这一重要蛋白质家族的生物学。这项工作的关键将是开发一种新的组合连接方法，该方法将用于以快速有效的方式生成趋化因子文库。这项工作还将寻求开发第一个针对PROTAC的CCL2。