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Novel Liquid Crystal Droplets for Detecting Toxins.

用于检测毒素的新型液晶液滴。

基本信息

批准号：
2232700
负责人：
金额：
--
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2232700
关键词：
Novel Liquid Crystal Droplets Detecting

项目摘要

Combating antimicrobial resistance is vital in all areas of medical practice. At present many of the diagnostic methods used do not give the desired instantaneous feedback and are relatively expensive to use. Our approach is to make phospholipid (biomembrane-like) coated liquid crystal droplets. Liquid crystals are ordered fluids and their orientation depends on the surface they are in contact with. The liquid crystal droplet will have distinctive optical properties that depend on the surface orientation. Hence, a change in the phospholipid layer will influence the liquid crystal droplet.This project will use microfluidics to produce coated liquid crystal droplets of a uniform size, with control over the alignment of the liquid crystal at the phopholipid interface. We are especially interested in understanding the relationship between the liquid crystal physical properties (elastic constants, polarity etc.) and the interaction with the lipid layer. This will allow us to fully understand some of the complex geometries that occur in the droplets as well as to optimize the materials that might be used in a device. Our exciting multidisciplinary approach uses liquid crystals in a new way and enhances our fundamental scientific understanding of liquid crystals, biomembranes and biomolecule interactions. Ultimately, we have the potential to provide a new way of diagnosing significant healthcare problems

对抗抗生素耐药性在医疗实践的所有领域都至关重要。目前使用的许多诊断方法不能给出所需的瞬时反馈，并且使用起来相对昂贵。我们的方法是制造磷脂（生物膜样）涂层的液晶液滴。液晶是有序的流体，它们的取向取决于它们所接触的表面。液晶液滴将具有取决于表面取向的独特光学性质。因此，磷脂层的变化将影响液晶液滴。本项目将使用微流体技术生产尺寸均匀的涂层液晶液滴，并控制磷脂界面处液晶的取向。我们特别感兴趣的是了解液晶物理性质（弹性常数，极性等）之间的关系。以及与脂质层的相互作用。这将使我们能够充分了解液滴中出现的一些复杂几何形状，并优化可能用于设备的材料。我们令人兴奋的多学科方法以新的方式使用液晶，并增强了我们对液晶，生物膜和生物分子相互作用的基础科学理解。最终，我们有可能提供一种诊断重大医疗保健问题的新方法。