Breaking bad: Do high-fat diets trigger ubiquitous bacteria to become bad?

绝命毒师：高脂肪饮食是否会导致无处不在的细菌变坏？

• 批准号: 2237869
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2237869
• 关键词: Breaking; bad; Do; fat; diets

We are what we eat. The food we consume shapes our gut microbiota, which in turn plays a key role in health and disease. Bilophila is a resident of the human gut microbiome and is a member of sulphite-reducing bacteria (SRB) that release the toxic molecule hydrogen sulphide (H2S) as a byproduct. H2S has been linked to colonic disorders and gut inflammation. High-fat diets are becoming more prevalent. Meat based high-fat diets are enriched with specific amino acids and in animal studies they are shown to promote the growth of Bilophila. However, their impact in humans is not yet established. Intriguingly, our recent work on cultivation and diversity analyses revealed that Bilophila is a common member of the human gut microbiome. This raises the following questions: are they detrimental to us? Can we develop specific diets or other intervention strategies to control their population? This multidisciplinary project aims to understand the dynamics of Bilophila in the gut microbiome and its relationship to diet and gut health using in vitro colon models, tissue culture, metagenomics, and metabolomics.

我们就是我们所吃的东西。我们消耗的食物塑造了我们的肠道微生物群，而肠道微生物群又在健康和疾病中发挥着关键作用。 Bilophila 是人类肠道微生物组的居民，也是亚硫酸盐还原菌 (SRB) 的成员，该细菌会释放有毒分子硫化氢 (H2S) 作为副产品。 H2S 与结肠疾病和肠道炎症有关。高脂肪饮食变得越来越普遍。以肉类为基础的高脂肪饮食富含特定氨基酸，在动物研究中，它们被证明可以促进嗜胆菌的生长。然而，它们对人类的影响尚未确定。有趣的是，我们最近的培养和多样性分析工作表明，Bilophila 是人类肠道微生物组的常见成员。这就提出了以下问题：它们对我们有害吗？我们可以制定特定的饮食或其他干预策略来控制它们的数量吗？这个多学科项目旨在利用体外结肠模型、组织培养、宏基因组学和代谢组学来了解肠道微生物组中嗜胆菌的动态及其与饮食和肠道健康的关系。