Resistance evolution in the presence of combination antibiotic therapy

联合抗生素治疗下耐药性的演变

• 批准号: 2241853
• 金额: --
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2241853
• 关键词: Resistance; evolution; presence; combination; antibiotic

Antimicrobial resistance (AMR) is a major global public health issue [1]. Antibioticcombination therapy is often used to prevent the spread of antibiotic resistance [2]. This presents a complex selection landscape for bacteria, with an interplay between mutation rates, fitness effects and epistasis determining the profile of the antibiotic resistant bacteria ultimately selected. This project will combine mathematical modelling with experimental analysis to explore resistance evolution within a pathogen group of importance in man and animals: the mycobacteria. The results will inform our understanding of the importance of heterogeneity in bacterial evolution but will also, ultimately, inform combination therapy design.

抗生素耐药性（AMR）是一个重大的全球公共卫生问题[1]。抗生素联合治疗通常用于防止抗生素耐药性的传播[2]。这为细菌提出了一个复杂的选择景观，突变率，适应性效应和上位性之间的相互作用决定了最终选择的抗生素耐药细菌的概况。该项目将联合收割机与实验分析相结合，以探索人类和动物中重要的病原体组：分枝杆菌内的抗性进化。这些结果将使我们了解细菌进化中异质性的重要性，但最终也将为联合治疗设计提供信息。