HYPERTENSION AMONG AFRICAN-AMERICANS

非裔美国人的高血压

• 批准号: 6642082
• 负责人: JEFFERY HUNTER YOUNG
• 金额: $ 14.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642082
• 关键词: African American; G protein; alcoholism /alcohol abuse; alleles; autonomic nervous system; blood pressure; cardiovascular disorder epidemiology; clinical research; cocaine; community; drug abuse; family genetics; gender difference; gene environment interaction; gene expression; gene interaction; genetic polymorphism; genotype; health behavior; human subject; hypertension; patient oriented research; renin angiotensin system; salt intake; siblings; socioeconomics; urban area

DESCRIPTION (provided by applicant): The investigators? goal is to become a clinician-scientist focused on African-American health and hypertension research using the tools of population genetics, molecular biology, and blood pressure (BP) physiology. To realize his goal, he designed a program of coursework, structured mentoring by senior investigators, and innovative research. With regards to continuing coursework, he was awarded a Master?s degree in health science in epidemiology this year and will continue advanced coursework at JHU and the JH Bloomburg School of Public Health in the fields of population genetics and molecular biology. In addition, he will continue to meet weekly with his sponsor and to meet regularly with his Advisory Committee of senior investigators. With the support of his sponsor and co-investigators, he proposes a case-control study of 300 African-American persons with severe hypertension admitted to the JH Hospital, 200 normotensive siblings, and 300 community-dwelling controls with a negative family history of hypertension and a low normal BP measured at two points in time four years apart. The prevalence of gene variants and candidate exposures will be compared between the cases and two sets of controls. In addition, the investigators will investigate gene-gene and gene-environment interactions. Through a newly formed collaboration with Dr. Aravinda Chakravarti and the McKusick-Nathans Institute of Genetic Medicine (IGM), the study will benefit from advanced genotyping technology that will allow the identification of hundreds of alleles at hundreds of loci. This study is distinguished by the recruitment of individuals representing extremes of the BP distribution, the recruitment of sibling controls, the characterization of proximal phenotypes, measurement of environmental exposures, and the use of advanced genotyping technology. In addition, the inclusion of inner city African-Americans will fill a major gap in the understanding of BP regulation. This ambitious study is feasible because of support from the GCRC, the infrastructure of the Core Laboratory of the IGM, the investigator?s 10-year relationship with the community, his demonstrated recruitment success, and the commitment of his mentors and sponsor. This research will build a foundation for a successful career as an independent investigator.

描述（申请人提供）：调查人员？目标是成为一个 临床医生科学家专注于非裔美国人健康和高血压 使用种群遗传学，分子生物学和血液的工具的研究 压力（BP）生理学。为了实现他的目标，他设计了一个计划 课程工作，高级研究人员的结构化指导以及创新的 研究。关于持续的课程，他被授予硕士学位？ 今年的流行病学健康科学学位，将继续提高 JHU的课程和JH Bloomburg公共卫生学院 种群遗传学和分子生物学。此外，他将继续 每周与他的赞助商开会，并定期与他的咨询 高级调查人员委员会。 在他的赞助商和共同研究人员的支持下，他提出了一个 300名患有严重高血压的非裔美国人的病例对照研究 被送入JH医院，200个正常的兄弟姐妹和300个 社区居民控制具有负面高血压的负面历史和 低正常的BP在相隔四年的时间分两个时间点测得。这 将比较基因变体和候选暴露的患病率 案例和两组控件。此外，调查人员还将 研究基因基因和基因环境相互作用。通过新的 与Aravinda Chakravarti博士和McKusick-Nathans建立了合作 遗传医学研究所（IGM），该研究将受益于先进 基因分型技术将允许识别数百种 等位基因数百个基因座。 这项研究以代表个人的招募来区分 BP分布的极端，同胞控制的募集， 近端表型的表征，环境的测量 暴露和使用先进的基因分型技术。另外， 包括内城非裔美国人将填补主要空白 了解BP调节。这项雄心勃勃的研究是可行的 GCRC的支持，IGM核心实验室的基础设施， 调查员与社区的10年关系，他的演示 招聘成功，以及他的导师和赞助商的承诺。这 研究将为成功的独立职业生涯奠定基础 研究者。