HYPERTENSION AMONG AFRICAN-AMERICANS

非裔美国人的高血压

• 批准号: 6642082
• 负责人: JEFFERY HUNTER YOUNG
• 金额: $ 14.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642082
• 关键词: African American; G protein; alcoholism /alcohol abuse; alleles; autonomic nervous system; blood pressure; cardiovascular disorder epidemiology; clinical research; cocaine; community; drug abuse; family genetics; gender difference; gene environment interaction; gene expression; gene interaction; genetic polymorphism; genotype; health behavior; human subject; hypertension; patient oriented research; renin angiotensin system; salt intake; siblings; socioeconomics; urban area

DESCRIPTION (provided by applicant): The investigators? goal is to become a clinician-scientist focused on African-American health and hypertension research using the tools of population genetics, molecular biology, and blood pressure (BP) physiology. To realize his goal, he designed a program of coursework, structured mentoring by senior investigators, and innovative research. With regards to continuing coursework, he was awarded a Master?s degree in health science in epidemiology this year and will continue advanced coursework at JHU and the JH Bloomburg School of Public Health in the fields of population genetics and molecular biology. In addition, he will continue to meet weekly with his sponsor and to meet regularly with his Advisory Committee of senior investigators. With the support of his sponsor and co-investigators, he proposes a case-control study of 300 African-American persons with severe hypertension admitted to the JH Hospital, 200 normotensive siblings, and 300 community-dwelling controls with a negative family history of hypertension and a low normal BP measured at two points in time four years apart. The prevalence of gene variants and candidate exposures will be compared between the cases and two sets of controls. In addition, the investigators will investigate gene-gene and gene-environment interactions. Through a newly formed collaboration with Dr. Aravinda Chakravarti and the McKusick-Nathans Institute of Genetic Medicine (IGM), the study will benefit from advanced genotyping technology that will allow the identification of hundreds of alleles at hundreds of loci. This study is distinguished by the recruitment of individuals representing extremes of the BP distribution, the recruitment of sibling controls, the characterization of proximal phenotypes, measurement of environmental exposures, and the use of advanced genotyping technology. In addition, the inclusion of inner city African-Americans will fill a major gap in the understanding of BP regulation. This ambitious study is feasible because of support from the GCRC, the infrastructure of the Core Laboratory of the IGM, the investigator?s 10-year relationship with the community, his demonstrated recruitment success, and the commitment of his mentors and sponsor. This research will build a foundation for a successful career as an independent investigator.

描述（由申请人提供）：研究者？目标是成为 专注于非洲裔美国人健康和高血压的临床科学家 使用群体遗传学、分子生物学和血液工具的研究 血压（BP）生理学。为了实现他的目标，他设计了一个 课程作业，由高级调查员进行结构化指导， research.至于继续学业，他被授予了硕士？S 在流行病学健康科学学位，今年将继续先进 JHU和JH布卢姆堡公共卫生学院的课程作业 群体遗传学和分子生物学。此外，他还将继续 每周与他的赞助商会面，并定期与他的顾问会面 高级调查员委员会。 在他的赞助商和合作研究者的支持下，他提出了一个 300例严重高血压非裔美国人的病例对照研究 200名血压正常的兄弟姐妹和300名 有高血压阴性家族史的社区居住对照， 在相隔四年的两个时间点测量的正常血压较低。的 将比较基因变异和候选暴露的患病率， 病例和两组对照。此外，调查人员将 研究基因-基因和基因-环境相互作用。通过一个新 与Aravinda Chakravarti博士和McKusick-Nathans合作 遗传医学研究所（IGM），这项研究将受益于先进的 基因分型技术，将允许识别数百个 数百个基因座上的等位基因。 这项研究的特点是招募了代表 BP分布的极端，同胞对照的招募， 近端表型的表征，环境 暴露，并使用先进的基因分型技术。此外该 包括市中心的非洲裔美国人将填补一个主要的空白， 了解BP规则。这项雄心勃勃的研究是可行的，因为 GCRC的支持，IGM核心实验室的基础设施， 调查员？他与社区有着10年的关系， 招聘的成功，以及他的导师和赞助商的承诺。这 研究将建立一个成功的职业生涯作为独立的基础 调查员