Structure and dynamics of class B1 G protein coupled receptors

B1类G蛋白偶联受体的结构和动力学

• 批准号: DP230102776
• 负责人: Prof Denise Wootten
• 金额: $ 54.66万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102776
• 关键词: Structure; dynamics; class; B1; protein

Cells within our body require cell surface proteins (receptors) to convert extracellular stimuli into an appropriate biological response. G protein-coupled receptors are the largest group of cell surface receptors. This project focuses on a subset of these receptors that have diverse and important functions in the central nervous system and the periphery, however there are many unanswered questions regarding the structure of these proteins, and how they regulate cellular signalling. The primary outcomes of this project will provide detailed mechanistic insights on how receptors bind their stimuli and how this results in in their activation to mediate fundamental signalling that is important for all living organisms.

我们体内的细胞需要细胞表面蛋白（受体）将细胞外刺激转化为适当的生物反应。G蛋白偶联受体是细胞表面受体中最大的一类。该项目侧重于这些受体的子集，这些受体在中枢神经系统和外周中具有多种重要功能，但关于这些蛋白质的结构以及它们如何调节细胞信号传导还有许多未解答的问题。该项目的主要成果将提供关于受体如何结合其刺激以及这如何导致其激活以介导对所有生物体都很重要的基本信号的详细机制见解。