Newborn Screening and the Parent-Infant Relationships

新生儿筛查和亲子关系

• 批准号: 6623125
• 负责人: AUDREY TLUCZEK
• 金额: $ 9.36万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6623125
• 关键词: behavior test; behavioral /social science research tag; congenital disorders; coping; cystic fibrosis; emotional adjustment; growth /development; human subject; hypothyroidism; interpersonal relations; longitudinal human study; mass screening; metabolism disorder diagnosis; newborn human (0-6 weeks); parent offspring interaction; patient oriented research; personality; postdoctoral investigator; psychological tests; psychology; questionnaires; sign /symptom; stress

The candidate is submitting a proposal for a K23 Award from the NICHD with a short-term career development goal of enhancing her research skills and a long-term goal of developing a program of research that includes clinical trials designed to evaluate the efficacy of psychosocial interventions for children with chronic illness and their families. To meet these goals, she proposes a career development plan that includes participation in the Clinical Investigator Preparatory Program (CIPP) offered through the University of Wisconsin Medical School. The proposed research project will evaluate the impact of newborn screening and diagnosis on the parent-infant relationship; examine the interactional mechanism that may contribute to a parent-infant relational disturbance; and identify parent, infant, and parent-infant dyadic variables that may serve as mediating factors in the quality of the parent-infant relationship. Four groups will be compared: a) families with infants who have CF diagnosed through newborn screening (CF-D), b) families with infants who are heterozygote CF mutation carriers identified through newborn screening (CF-C), c), families with infants who have congenital hypothyroidism (CH) diagnosed through newborn screening (CH), and d) families who have healthy infants (H) with normal screening results. The design will consist of multi-modal methods including empirically validated self- report measures, observational measures, and chart review. Data will be collected on parent, infant, and parent-infant interactional variables. Independent variables will consist of parents' level of task-oriented behaviors and emotional responsiveness in interactions with their infants as measured by an observational method. The primary dependent variable will be the quality of the parent-infant attachment relationship as measured by parental self-report and an observational method. Mediating factors will include parental psychological symptoms, stress, and coping style, as well as infant temperament, developmental status, and illness severity. Families will be followed and data collected over one year to document parent-child relationship changes over the infant's first year. Demographic variables will be controlled statistically. This study will provide important data for development of an intervention study for this genetically at risk population.

该候选人正在向NICHD的K23奖提交一份提案，其短期职业发展目标是提高她的研究技能，长期目标是发展一个研究项目，包括旨在评估慢性疾病儿童及其家庭心理社会干预效果的临床试验。为了实现这些目标，她提出了一项职业发展计划，其中包括参加威斯康星大学医学院提供的临床研究者预备课程（CIPP）。拟开展的研究项目将评估新生儿筛查和诊断对亲子关系的影响；检查可能导致亲子关系障碍的相互作用机制；并确定可能作为亲子关系质量中介因素的父母、婴儿和父母-婴儿二元变量。将比较四组：a)通过新生儿筛查诊断为CF的婴儿家庭（CF- d）， b)通过新生儿筛查确定为CF突变杂合子携带者的婴儿家庭（CF- c）， c)通过新生儿筛查诊断为先天性甲状腺功能减退症（CH）的婴儿家庭（CH）， d)筛查结果正常的健康婴儿家庭(H)。设计将由多模态方法组成，包括经验验证的自我报告测量、观察测量和图表回顾。将收集父母、婴儿和父母-婴儿互动变量的数据。自变量包括父母在与婴儿互动时的任务导向行为和情绪反应水平，通过观察方法测量。主要的因变量将是亲子依恋关系的质量，通过父母自我报告和观察方法来衡量。中介因素包括父母的心理症状、压力和应对方式，以及婴儿的气质、发育状况和疾病严重程度。研究人员将对这些家庭进行为期一年的跟踪调查，收集数据，以记录婴儿一岁期间亲子关系的变化。人口统计变量将在统计上加以控制。本研究将为开展针对这一遗传风险人群的干预研究提供重要数据。