Newborn Screening and the Parent-Infant Relationships

新生儿筛查和亲子关系

• 批准号: 6780901
• 负责人: AUDREY TLUCZEK
• 金额: $ 9.64万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6780901
• 关键词: behavior test; behavioral /social science research tag; congenital disorders; coping; cystic fibrosis; emotional adjustment; growth /development; human subject; hypothyroidism; interpersonal relations; longitudinal human study; mass screening; metabolism disorder diagnosis; newborn human (0-6 weeks); parent offspring interaction; patient oriented research; personality; postdoctoral investigator; psychological tests; psychology; questionnaires; sign /symptom; stress

The candidate is submitting a proposal for a K23 Award from the NICHD with a short-term career development goal of enhancing her research skills and a long-term goal of developing a program of research that includes clinical trials designed to evaluate the efficacy of psychosocial interventions for children with chronic illness and their families. To meet these goals, she proposes a career development plan that includes participation in the Clinical Investigator Preparatory Program (CIPP) offered through the University of Wisconsin Medical School. The proposed research project will evaluate the impact of newborn screening and diagnosis on the parent-infant relationship; examine the interactional mechanism that may contribute to a parent-infant relational disturbance; and identify parent, infant, and parent-infant dyadic variables that may serve as mediating factors in the quality of the parent-infant relationship. Four groups will be compared: a) families with infants who have CF diagnosed through newborn screening (CF-D), b) families with infants who are heterozygote CF mutation carriers identified through newborn screening (CF-C), c), families with infants who have congenital hypothyroidism (CH) diagnosed through newborn screening (CH), and d) families who have healthy infants (H) with normal screening results. The design will consist of multi-modal methods including empirically validated self- report measures, observational measures, and chart review. Data will be collected on parent, infant, and parent-infant interactional variables. Independent variables will consist of parents' level of task-oriented behaviors and emotional responsiveness in interactions with their infants as measured by an observational method. The primary dependent variable will be the quality of the parent-infant attachment relationship as measured by parental self-report and an observational method. Mediating factors will include parental psychological symptoms, stress, and coping style, as well as infant temperament, developmental status, and illness severity. Families will be followed and data collected over one year to document parent-child relationship changes over the infant's first year. Demographic variables will be controlled statistically. This study will provide important data for development of an intervention study for this genetically at risk population.

候选人正在提交一份来自NICHD的K23奖的提案，其短期职业发展目标是提高她的研究技能，长期目标是制定一项研究计划，其中包括旨在评估心理社会干预措施对慢性病儿童及其家庭的有效性的临床试验。为了实现这些目标，她提出了一个职业发展计划，其中包括通过威斯康星州医学院提供的临床研究者预备计划（CIPP）的参与。拟议的研究项目将评估新生儿筛查和诊断对父母-婴儿关系的影响;检查可能导致父母-婴儿关系障碍的干预机制;并确定父母，婴儿和父母-婴儿二元变量，这些变量可能作为父母-婴儿关系质量的中介因素。将比较四组：a）具有通过新生儿筛查（CF-D）诊断为CF的婴儿的家庭，B）具有通过新生儿筛查（CF-C）鉴定为杂合子CF突变携带者的婴儿的家庭，c）具有通过新生儿筛查（CH）诊断为先天性甲状腺功能减退（CH）的婴儿的家庭，以及d）具有筛查结果正常的健康婴儿（H）的家庭。设计将包括多模式方法，包括经验验证的自我报告措施，观察措施和图表审查。将收集关于父母、婴儿和父母-婴儿间期变量的数据。自变量将包括父母的任务导向行为和情绪反应的水平，在与他们的婴儿的互动，通过观察方法测量。主要的因变量将是通过父母自我报告和观察方法测量的亲子依恋关系的质量。中介因素将包括父母的心理症状，压力和应对方式，以及婴儿的气质，发育状况和疾病的严重程度。家庭将被跟踪，并在一年内收集数据，以记录婴儿第一年的亲子关系变化。将对人口统计学变量进行统计学控制。本研究将为该遗传风险人群的干预研究提供重要数据。