Treatment of Psychotic Disorders in Youth

描述（由申请人提供）：拟议职业的主要目标 发展活动是为了提供扩大的知识基础，技能， 临床试验设计和分析，以及我需要的研究经验， 成为一名独立的调查员，专注于干预研究， 患有精神疾病的儿童和青少年有一个缺乏 治疗精神病的研究，特别是精神药理学研究 青春期的疾病我的主要兴趣是确定急性和长期 特定抗精神病药物在青少年中的疗效和耐受性 精神分裂症谱系疾病。中期目标是开发更安全、 更有效的治疗儿童精神病的方法最终，技能和 在这个职业发展计划的过程中获得的知识将增加 我利用干预研究的结果来推断 儿科精神病的病理生理学获得的技能， 该奖项的课程也将推广到严格的干预研究， 其他严重的神经发育障碍如自闭症。 我的职业发展计划包括1）设计方面的教学课程， 临床试验分析，2）儿童精神病学专家的指导 临床试验，在分析和监管的影响，临床 试验和儿童精神分裂症，以及3）指导的研究活动 Jeff Lieberman博士涉及非典型抗精神病药物的评价， 小儿精神病我建议的指导研究活动是：1）a 多中心、随机、对照试验（TEOSS，最近获得资助），2） 一项开放的前瞻性研究，对接受 抗精神病药物，以及3）新开发的抗精神病药物的试点研究。项目 1，TEOSS，比较了吗茚酮、利培酮和 奥氮平治疗精神分裂症和儿童和青少年的情感障碍。 项目2研究精神病青年三年内的复发率 最初用不同的抗精神病药物治疗项目3包括试点 新开发的抗精神病药包括齐拉西酮，阿立哌唑， 和伊潘立酮。协调项目？和3与TEOSS将允许我使用 许多相同的病例报告表，相同的数据库系统，以及类似的 分析。此外，将有可能大体上比较以下数据： 项目本职业发展计划及拟开展的研究活动 这将极大地促进我从一个临床医生到少数几个 独立调查人员专注于对青少年的干预研究， 精神病

DESCRIPTION (provided by applicant): The primary objectives of the proposed career development activities are to provide the expanded knowledge base, skills in clinical trial design and analysis, and research experiences that I need to become an independent investigator with a focus on intervention research in children and adolescents with psychotic disorders. There is a dearth of research, particularly psychopharmacologic, on the treatment of psychotic disorders in youth. My primary interest is to determine the acute and long-term efficacy and tolerability of specific antipsychotics in youth with schizophrenia spectrum illnesses. Intermediate goals are to develop safer and more effective treatments for psychosis in children. Ultimately the skills and knowledge gained in the course of this career development program will increase my ability to use the results of intervention studies to make inferences about the pathophysiology of pediatric psychotic disorders. The skills gained in the course of this award will also Generalize to rigorous intervention studies in other severe neurodevelopmental disorders like autism. My career development plan includes 1) didactic courses in the design and analysis of clinical trials, 2) tutorials with experts in child psychiatry clinical trials, in the analysis and regulatory implications of clinical trials, and in childhood schizophrenia, and 3) research activities mentored by Dr. Jeff Lieberman involving the evaluation of atypical antipsychotics in pediatric psychosis. The mentored research activities that I propose are 1) a multisite, randomized, controlled trial (TEOSS, which was recently funded), 2) an open, prospective study of long-term outcome for youth treated with antipsychotics, and 3) pilot studies of newly developed antipsychotics. Project 1, TEOSS, compares the efficacy and tolerability of molindone, risperidone, and olanzapine in schizophrenia and schizoaffective in children and adolescents. Project 2 examines relapse incidence over three years in psychotic youth initially treated with different antipsychotics. Project 3 consists of pilot studies of newly developed antipsychotics including ziprasidone, aripiprazole, and iloperidone. Coordinating projects ? and 3 with TEOSS will'allow me to use many of the same case report forms, the same database systems, and similar analyses. Further, it will be possible to generally compare data between projects. This career development plan and the proposed research activities will greatly facilitate my transition from a clinician to one of the handful of independent investigators focused on intervention studies in youth with psychotic illnesses.