Turning bacterial cyclopropane synthase enzymes into biocatalysts for the green and sustainable manufacturing of chemicals and drugs

将细菌环丙烷合酶转化为生物催化剂，用于化学品和药物的绿色和可持续制造

• 批准号: 2242020
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2242020
• 关键词: Turning; bacterial; cyclopropane; synthase; enzymes

The Nobel Prize 2018 in chemistry has been awarded to green chemists confirming the importance and urgency for the scientific community to move towards the development of sustainable processes for producing pharmaceuticals, agrochemicals, and other chemicals. This project aims to study unique bacterial enzymes, the cyclopropane fatty acid synthases (CFAS), responsible for the synthesis of mycolic acid in bacteria. A series of CFAS enzymes will be cloned, expressed, purified and eventually turned into biocatalysts for the sustainable manufacturing of drugs and chemicals. This project will develop new biocatalysts for challenging cyclopropanation biotransformations combining molecular biology, analytical and chemical approaches.

2018年诺贝尔化学奖授予了绿色化学家，这证实了科学界发展可持续生产药物、农用化学品和其他化学品的重要性和紧迫性。该项目旨在研究独特的细菌酶，环丙烷脂肪酸脱氢酶（CFAS），负责细菌中分枝菌酸的合成。一系列CFAS酶将被克隆、表达、纯化，并最终转化为可持续生产药物和化学品的生物催化剂。该项目将结合分子生物学、分析和化学方法开发新的生物催化剂，用于具有挑战性的环丙烷化生物转化。