DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY

老年人的抑郁症和水痘疫苗的试验

• 批准号: 6640742
• 负责人: Michael R Irwin
• 金额: $ 45.96万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640742
• 关键词: Herpesviridae vaccine; aging; antibody titering; cellular immunity; clinical research; clinical trials; comorbidity; enzyme linked immunosorbent assay; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; interferons; interleukin 10; interleukin 2; major depression; microorganism immunology; neuroimmunomodulation; shingles; varicella zoster virus

DESCRIPTION (adapted from investigator's abstract): Compelling evidence has shown that inescapable stress, a putative animal model of depression, increases susceptibility to viral diseases such as herpes simplex, influenza, and coxsackie virus infections via alterations in immune function. However, translation of these basic observations into the clinical setting is limited, and the immunological consequences of major depression and their possible clinical relevance to infectious diseases remain unknown. Moreover, immunological studies of depressed subjects have not evaluated disease specific immune measures nor assayed in vivo immune responses that correlate with outcome. This study hypothesizes that older adults with major depression are at increased risk for reactivation of varicella-zoster virus (VZV) infection. Because much evidence indicates that cell mediated immunity plays a critical role in limiting the occurrence of herpes zoster (HZ) and its complications, the effect of major depression on VZV-specific cellular immunity will be examined. Using a disease specific approach, this study will also evaluate the integrity of an integrated, in vivo immune response to VZV vaccine in depressed subjects as compared to controls. The specific aims of this project are to: 1) determine whether major depressive disorder is associated with declines in VZV specific immunity in adults 60 years of age and older; and 2) evaluate whether major depressive disorder attenuates the magnitude or duration of vaccine-stimulated virtue of their older age are at increased risk for HZ and assaying VZV specific immunological measures that are known to correlate with the occurrence and severity of HZ and its complications, this study advances our model, another major strength, will yield substantial new information about how the immune system of depressed subjects responds to an antigen of an infectious pathogen.

描述（改编自研究者的摘要）：令人信服的证据 研究表明，不可避免的压力（一种假定的抑郁症动物模型）会增加 容易感染病毒性疾病，如单纯疱疹、流感等 柯萨奇病毒通过免疫功能改变而感染。然而， 这些基本观察到临床环境的转化是有限的， 以及重度抑郁症的免疫学后果及其可能的 与传染病的临床相关性仍不清楚。而且， 抑郁症受试者的免疫学研究尚未评估疾病特异性 免疫测量或测定与相关的体内免疫反应 结果。这项研究假设患有重度抑郁症的老年人处于 水痘带状疱疹病毒（VZV）感染重新激活的风险增加。 因为大量证据表明细胞介导的免疫在 在限制带状疱疹（HZ）及其并发症的发生方面的作用， 重度抑郁症对 VZV 特异性细胞免疫的影响 检查了。这项研究还将使用针对特定疾病的方法来评估 抑郁症患者对 VZV 疫苗的综合体内免疫反应的完整性 受试者与对照组相比。该项目的具体目标是：1) 确定重度抑郁症是否与 VZV 下降有关 60 岁及以上成年人的特异性免疫力； 2）评估是否 重度抑郁症会减弱抑郁症的严重程度或持续时间 由于年龄较大而受到疫苗刺激，患带状疱疹的风险增加 检测已知与相关的 VZV 特异性免疫学指标 HZ及其并发症的发生和严重程度，本研究进展 我们的模型的另一个主要优势是，将产生大量关于以下方面的新信息： 抑郁症受试者的免疫系统如何对抗原做出反应 传染性病原体。