COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER

人格障碍的合作纵向研究

• 批准号: 6639021
• 负责人: M. Tracie Shea
• 金额: $ 45.98万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6639021
• 关键词: avoidance behavior; behavioral /social science research tag; borderline personality disorder; comorbidity; cooperative study; diagnosis design /evaluation; disease /disorder etiology; functional ability; health care service utilization; human subject; human therapy evaluation; longitudinal human study; major depression; mental disorder diagnosis; obsessive compulsive disorder; outcomes research; patient oriented research; personality disorders; prognosis; schizoid personality; social psychology

DESCRIPTION (APPLICANT'S ABSTRACT): The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPD), avoidant (AVPD), and obsessive-compulsive (OCPD). The present application continues a multi-site collaborative effort to follow a carefully diagnosed sample of 668 subjects having either these representative PDs or major depressive disorder (MDD) (controls) for the period from 3 to a maximum of 6 years after recruitment. Sixty new minority subjects will be recruited and followed for at least 2 years. Using a prospective, longitudinal, repeated measures design, we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders, thus addressing an important gap in our knowledge. The extended period of follow-up is essential to discern clinically meaningful descriptions of course and outcome and their determinants. The sample is large enough and sufficiently diverse demographically to attain a unique array of results generalizable to most clinical settings. To accomplish our overall aim, we propose three approaches: I. descriptive, II. predictive, and III. validating. The descriptive approach will provide data on diagnostic stability of PDs, on presence and course of comorbid Axis I disorders, on persistence of functional impairment, and on utilization of health care resources that allow comparison between the PDs and to similar data on Axis I disorders. The predictive approach will identify clinically meaningful determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs.

描述（申请人摘要）： 的总体目标 本研究旨在提供一个全面的过程和结果 四种特定的人格障碍（PD）：典型型（STPD），边缘型 (BPD)、回避型（AVPD）和强迫型（OCPD）。本 应用程序继续进行多站点协作， 668例患有这些代表性PD或 重度抑郁症（MDD）（对照组），持续时间为3至最大值 招募后6年。将招募60名新的少数民族受试者， 随访至少2年。采用前瞻性、纵向、重复性 措施的设计，我们将制定相同的基本知识课程， 以前类似调查产生的PD结果， 情感和焦虑障碍，从而解决了一个重要的差距，在我们的 知识延长随访期对于临床识别 有意义的描述过程和结果及其决定因素。的 样本足够大，在人口统计学上足够多样化， 一系列独特的结果可推广到大多数临床环境。 为了实现我们的总体目标，我们提出了三个途径：一。描述，二。 预测，和III。验证描述性方法将提供以下数据： PD的诊断稳定性，关于合并症轴I的存在和病程 功能障碍的持续性，以及使用 允许在PD之间进行比较的医疗保健资源和类似数据 第一轴紊乱预测方法将在临床上识别 PD内和PD间预后的有意义的决定因素。所述验证 方法将检查描述性和纵向特征的同质性 对于PD。